Exposure to alendronate is associated with a lower risk of bone metastases in osteoporotic women with early breast cancer

Journal of Bone Oncology
Vanessa RouachDaniel Cohen

Abstract

Bisphosphonate (BP) treatment to prevent bone loss in breast cancer patients is already well established. However, data on the association between oral BP exposure before cancer diagnosis and disease outcomes in patients with early breast cancer are still scarce. Limited information is available on alendronate, the most common oral agent for the treatment of post-menopausal osteoporosis, regarding the association with bone metastases. To examine the association between oral bisphosphonate exposure before cancer diagnosis and the risk of bone metastases in osteoporotic women diagnosed with early breast cancer. This historical cohort study was conducted at the oncology division at Tel Aviv Medical Center. The study population included post-menopausal women with early breast cancer, diagnosed between 2002 and 2012. Data on cancer characteristics, diagnosis of osteoporosis, prior bisphosphonate exposure and outcome were collected from medical files. Among 297 osteoporotic women identified, 145 (49%) were treated with bisphosphonates (alendronate in 90% of the cases) before cancer diagnosis. BP-treated women were significantly older than the BP-naïve ones (67.9 years vs 64.6 years, p = 0.01), but comparable in risk factors and disea...Continue Reading

Citations

Oct 12, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ian R ReidGregory D Gamble
Aug 1, 2020·Current Osteoporosis Reports·Emma O Billington, Ian R Reid
Jul 25, 2019·Cancers·Alexus D Kolb, Karen M Bussard
Mar 4, 2020·Breast Cancer Research and Treatment·Irene E G van HellemondUNKNOWN Dutch Breast Cancer Research Group (BOOG)
Nov 16, 2020·The FEBS Journal·Maartje P F DamenColinda L G J Scheele
Jun 7, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bárbara CostaNuno Vale
Aug 15, 2019·Oncology·Nicole ZulaufGerhard Maximilian Oremek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Hamed KhaliliAndrew T Chan
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Rowan T ChlebowskiRobert B Wallace
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Chia-Hung ChiangHsin-Bang Leu
© 2022 Meta ULC. All rights reserved