Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario

Environment International
Li BaiHong Chen

Abstract

Long-term exposure to ambient air pollution has been linked to cardiovascular mortality, but the associations with incidence of major cardiovascular diseases are not fully understood, especially at low concentrations. We aimed to investigate the associations between exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), ozone (O3), redox-weighted average of NO2 and O3 (Ox) and incidence of congestive heart failure (CHF) and acute myocardial infarction (AMI). Our study population included all long-term residents aged 35-85 years who lived in Ontario, Canada, from 2001 to 2015 (~5.1 million). Incidence of CHF and AMI were ascertained from validated registries. We assigned estimates of annual concentrations of pollutants to the residential postal codes of subjects for each year during follow-up. We estimated hazard ratios (HRs) and 95% CIs for each pollutant separately using Cox proportional hazards models. We examined the shape of concentration-response associations using shape-constrained health impact functions. From 2001 to 2015, there were 422,625 and 197,628 incident cases of CHF and AMI, respectively. In the fully adjusted analyses, the HRs of CHF corresponding to each interquartile range increase in exposure ...Continue Reading

References

Feb 9, 2005·Circulation·Jean-Bernard RuidavetsJean Ferrières
Jun 30, 2006·Journal of the Air & Waste Management Association·C Arden Pope, Douglas W Dockery
Feb 3, 2007·The New England Journal of Medicine·Kristin A MillerJoel D Kaufman
May 15, 2007·Journal of Occupational and Environmental Medicine·Yvonne de KluizenaarPaul E de Jong
Jan 17, 2008·Environmental Health Perspectives·Joel SchwartzLouise Ryan
Feb 6, 2009·Journal of General Internal Medicine·David H AuKatharine A Bradley
Jan 6, 2010·Environmental Health Perspectives·Robin C PuettFrancine Laden
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Feb 3, 2011·Occupational and Environmental Medicine·Marloes EeftensGerard Hoek
Apr 2, 2011·Environmental Health Perspectives·Perry HystadPaul Demers
Jun 15, 2011·Blood·Massimo Franchini, Pier Mannuccio Mannucci
Jun 28, 2011·American Journal of Respiratory and Critical Care Medicine·Michael J LipsettLeslie Bernstein
Nov 29, 2011·Toxicology Letters·Timothy D NelinLoren E Wold
Jul 14, 2012·Journal of the American Society of Hypertension : JASH·Lisa CohenJohn P Forman
Jul 20, 2012·Environmental Health : a Global Access Science Source·Giulia CesaroniFrancesco Forastiere
Dec 4, 2012·Environmental Health Perspectives·Jaime MadriganoJoel Schwartz
Dec 12, 2012·Epidemiology·Richard W AtkinsonDerek G Cook
Jun 29, 2014·Environmental Research·Hwashin H ShinRichard T Burnett
Oct 25, 2014·Environmental Health Perspectives·Aaron van DonkelaarBrian L Boys
Jun 4, 2015·Environmental Health Perspectives·Liuhua ShiJoel D Schwartz
Aug 12, 2015·Environmental Science & Technology·Aaron van DonkelaarRichard T Burnett
Aug 26, 2015·Environmental Health Perspectives·Anna OudinLars-Göran Nilsson
Apr 22, 2016·International Journal of Epidemiology·Hong ChenRichard T Burnett
Sep 17, 2017·Environment International·Hong ChenRichard T Burnett
Jan 4, 2018·Nature Reviews. Cardiology·Michael B HadleyValentin Fuster
May 11, 2018·Epidemiology·Richard W AtkinsonRobert L Maynard
Sep 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Richard BurnettJoseph V Spadaro
Oct 20, 2018·Journal of the American College of Cardiology·Sanjay RajagopalanRobert D Brook

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Citations

Mar 18, 2020·Environmental Health : a Global Access Science Source·James P FabisiakAlbert A Presto
May 23, 2020·Environmental Health Perspectives·Johannah CramerZorana J Andersen
May 20, 2020·Clinical and Experimental Hypertension : CHE·Camila KochiSamina Salim
Jan 1, 2021·Journal of the American Heart Association·Stacey E AlexeeffStephen Sidney
Jan 30, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Agnes Maria LedererNandu Goswami
Apr 30, 2021·Environmental Epidemiology·Youn-Hee LimZorana J Andersen
May 27, 2021·Environmental Science and Pollution Research International·Mostafa LeiliAbbas Afkhami
Jun 10, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kathryn WolhuterJason C Kovacic
Oct 7, 2021·Journal of the American Heart Association·Youn-Hee LimZorana J Andersen
Nov 2, 2021·Environmental Science & Technology·Aaron van DonkelaarRandall V Martin

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