Exposure to arsenite and cadmium induces organotoxicity and miRNAs deregulation in male rats

Environmental Science and Pollution Research International
Farah MumtazOla H El-Habit

Abstract

Sodium arsenite (NaAsO2) and cadmium chloride (CdCl2) are two prime examples of un-biodegradable compounds that accumulate in the ecosystems causing great threats to human health and produce severe adverse effects. However, their joint toxicities are poorly understood in mammals. This study aimed to identify the effect of exposure to NaAsO2 (5 mg/kg, by oral gavage) and CdCl2 (1 mg/kg injected interperitoneal, i.p.) either alone or in combinations after 14 and 28 days on oxidative stress, antioxidant enzyme activities, and histopathological changes. The results revealed a downregulation of miR-146a also, in miR-let7a after 14 days and a notable upregulation after 28 days. However, administrations of their combinations for 14 days caused downregulated miR-146a and miR-let7a. However, upregulation miR-let7a was observed only after 28 days. Organotoxicity of liver results in a remarkable increase in oxidative stress biomarkers by the two metals either alone or in combinations. A remarkable decrease was noted in an antioxidant enzyme activity indicating a defect in the antioxidant defense system. Also, CdCl2 alone showed remarkable liver histopathological changes. This study concluded that there was a close relationship of high epi...Continue Reading

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Citations

Jun 11, 2020·Journal of the Science of Food and Agriculture·Wafa A Al-MegrinManal El-Khadragy
Sep 30, 2020·Environmental Science and Pollution Research International·Daifullah Al AboudRami B Kassab
Oct 21, 2020·Biological Trace Element Research·Chunlin YuYiping Liu
Jan 18, 2021·Biological Trace Element Research·Rasha S AlbeltagyOla H El-Habit
Apr 18, 2021·Biological Trace Element Research·Munir OzturkTomonori Kawano

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