Exposure to Cryptococcus neoformans var. gattii--a seroepidemiological study

Transactions of the Royal Society of Tropical Medicine and Hygiene
R A SeatonD A Warrell

Abstract

An enzyme-linked immunosorbent assay was developed to study prevalence of immunoglobulin G (IgG) antibody to non-capsular Cryptococcus neoformans var. gattii antigen in a population of healthy Papua New Guinea (PNG) controls and patients. Patients with acute C. neoformans var. gattii meningitis had elevated levels of IgG which declined significantly following treatment (P = 0.034). Levels in the sera of convalescent patients were significantly higher than those in PNG controls (P < 0.001), which in turn were significantly higher than in a UK control group (P < 0.001). Clear differences were observed amongst the PNG controls. Adults had significantly higher levels than children (P = 0.002) and men had significantly higher levels than women (P = 0.047). No difference was observed between levels in patient-related and unrelated controls. IgG responses in PNG controls mirror the prevalence of disease in this population. It is postulated that exposure to C. neoformans var. gattii is less common in children and women due to some as yet unidentified behavioural difference and that exposure occurs away from the home environment.

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Citations

Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ChenK Byth
Feb 2, 2006·Journal of the American Veterinary Medical Association·Colleen G DuncanJohn Campbell
Sep 24, 2011·Medical Mycology·Julie HarrisTom Chiller
Jun 21, 2011·Microbes and Infection·Edmond J ByrnesJoseph Heitman
Sep 4, 2008·Toxicon : Official Journal of the International Society on Toxinology·Wei-jian JiangShu-jin Zhao
Jul 16, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Monica ChanTim Barkham
Oct 4, 2014·Clinical Microbiology Reviews·Sharon C-A ChenTania C Sorrell
Nov 11, 2017·Future Microbiology·Rafael Melo Santos de Serpa BrandãoSemiramis Jamil Hadad do Monte
Jan 1, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·R A SeatonD A Warrell
Sep 2, 2011·Trends in Microbiology·Vishnu Chaturvedi, Sudha Chaturvedi

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