Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits.

Scientific Reports
Thomas P van der MeerJana V van Vliet-Ostaptchouk

Abstract

Endocrine Disrupting Chemicals (EDCs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to EDCs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and EDC concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR < 0.009). Associations for triglyceride, HDL-cholesterol, glucose and blood pressure were not. Linearity was confirmed for sign...Continue Reading

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Citations

Oct 13, 2020·Environmental Research·Thomas P van der MeerJana V van Vliet-Ostaptchouk
Jun 3, 2021·Nutrients·Virginia Robles-AguileraAna Rivas
Aug 5, 2021·Environmental Science and Pollution Research International·Ting YinHaifeng Zhang
Feb 1, 2022·Environmental Science and Pollution Research International·Hai Duc NguyenMin-Sun Kim

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Methods Mentioned

BETA
amputation

Software Mentioned

Lifelines

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