Exposure to environmental tobacco smoke and urinary 1-hydroxypyrene levels in preschool children

The Kaohsiung Journal of Medical Sciences
Hsiu-Ting TsaiDavid C Christiani

Abstract

Environmental tobacco smoke (ETS) contains relatively high concentrations of polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene, is a good indicator of PAH exposure in occupational studies. In this study, we investigated the relationship between urinary 1-OHP concentration and ETS exposure in preschool children. Forty preschool children, aged 24-76 months, were studied during November and December, 1999. Two spot-urine specimens (one in the morning immediately after the subject woke up and the other at night before the subject went to bed) were collected 1 day after completion of a questionnaire, in order to determine 1-OHP concentrations by fluorescent spectrophotometry. Overall, urinary 1-OHP concentrations were relatively low but detectable (morning: median, 0.021 microg/g creatinine; range, 0.002-1.019 microg/g creatinine; night: median, 0.015 microg/g creatinine; range, 0.002-1.328 microg/g creatinine). Multiple linear regression analyses revealed that the total number of cigarettes smoked by the children's fathers during the 3 days prior to collection of the urine specimens was significantly associated with their urinary 1-OHP concentrations, after adjusting for other confound...Continue Reading

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Citations

Nov 21, 2008·International Archives of Occupational and Environmental Health·Kyoung-Ho LeeDaehee Kang
Aug 2, 2011·Environmental Research·Suh-Woan HuChang-Chuan Chan
Nov 14, 2016·International Archives of Occupational and Environmental Health·Samaneh ShahsavaniMohammad Fararouei
Dec 2, 2004·Mutation Research·Kirsti Husgafvel-Pursiainen
Jan 24, 2015·International Journal of Environmental Health Research·Marsha K MorganNancy K Wilson
Aug 7, 2009·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Shih-Hsien ChangChung-Yih Kuo
Mar 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Plernpit Suwan-ampaiJacqueline Agnew

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