Exposure to environmentally relevant concentrations of malathion induces significant cellular, biochemical and histological alterations in Labeo rohita

Pesticide Biochemistry and Physiology
Subrata KarmakarShamee Bhattacharjee

Abstract

The extensive use of malathion, an organophosphate pesticide, raises the possibility of its undesirable toxicity to non-target organisms. Agricultural run-off and vector control sprays are the major sources of exposure to this pesticide for aquatic organisms. Some earlier studies have reported the presence of malathion at concentrations ranging from 18.12μg/L to 105.2μg/L in various water samples. In this study, we have tested the hypothesis that these sub-lethal yet environmentally significant concentrations of malathion has serious toxicological implications on the fingerlings of Labeo rohita. Exposure to increasing concentration of malathion (10, 50 and 100μg/L) was reflected in the serum concentration of the pesticide and also in the inhibition of acetylcholinesterase activity in fish brains. Increased abnormalities in liver function test coupled with a rise in the oxidative stress response were observed in gills, liver and kidney. However, the increase in antioxidant enzyme activities like superoxide dismutase and glutathione-S-transferase by malathion exposure suggested a hormetic response. Tissue injury due to malathion was evident from the morphological and nuclear anomalies in the H-E stained sections of gill, liver an...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T S GillJ Pande
Jan 1, 1994·Bulletin of Environmental Contamination and Toxicology·H M DuttaC Richmonds
Feb 6, 2003·Ecotoxicology and Environmental Safety·P M C S De Silva, L A Samayawardhena
Aug 22, 2003·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·E I Cengiz, E Unlü
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Apr 6, 2006·FEMS Microbiology Reviews·Brajesh K Singh, Allan Walker
Jul 3, 2007·The Journal of Experimental Biology·Göran E Nilsson
Aug 28, 2007·American Journal of Epidemiology·Matthew R BonnerMichael C R Alavanja
Apr 3, 2008·Journal of Basic and Clinical Physiology and Pharmacology·M DavidV R Naik
Nov 26, 2008·Journal of Basic and Clinical Physiology and Pharmacology·Vineetkumar K Patil, M David
Jun 6, 2009·Ecotoxicology and Environmental Safety·Mariana AstizCarlos Alberto Marra
Nov 8, 2012·Bulletin of Environmental Contamination and Toxicology·Hamid KaryabAkram Bahojb
Dec 4, 2012·International Journal of Environmental Research and Public Health·Md Alamgir Zaman ChowdhurySiew Hua Gan
Jul 10, 2013·Environmental Monitoring and Assessment·Vineetkumar K Patil, Muniswamy David
Nov 2, 2013·Current Neuropharmacology·Mirjana B ColovićVesna M Vasić
Feb 2, 2015·Environmental Monitoring and Assessment·Akriti AgarwalL K Thakur

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Citations

Nov 12, 2017·BMJ Case Reports·Kei YokotaTadashi Okamoto
Apr 28, 2019·Environmental Science and Pollution Research International·Arumugam StalinMohamed Saiyad Musthafa
Feb 11, 2021·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Amir DelavarFatemeh Rahimi Anbarkeh

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