Exposure to ethanol and nicotine during the brain growth spurt: spatial DMP performance in male rats

Pharmacology, Biochemistry, and Behavior
T A GirardP E Wainwright

Abstract

Male Long-Evans rats were reared artificially and, using a 2x2 design, were exposed from postnatal days (PD) 6-9 to ethanol (ET: 6.5 g kg(-1) day(-1) "binge" exposure) and/or nicotine bitartrate (NIC: 6 mg kg(-1) day(-1) continuous exposure) via gastrostomy tubes. Controls were administered maltose-dextrin in amounts isocaloric to ET and/or sodium bitartrate. A fifth suckled-control group was reared normally. NIC accelerated eye opening on PD 14; whereas ET delayed eye opening and hindlimb support on PD 16. Beginning in postnatal week 7, rats were tested on a spatial delayed matching-to-place (DMP) version of the Morris water maze, which entailed a series of problems, each consisting of search and recall trials, that required the rats to use extra-maze cues to locate a hidden escape platform. In Phase 1 of testing, the ET-exposed groups were impaired in the recall trials, but there was no effect of NIC. A longer encoding time (45 vs. 10 s) improved performance across all groups. In contrast, acute administration of NIC (0.1 mg/kg ip) immediately prior to testing in Phase 2 failed to improve performance in any group. In conclusion, these results confirm previous findings of impaired spatial DMP-task performance in ET-exposed rat...Continue Reading

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Citations

Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Timothy B Johnson, Charles R Goodlett
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D SaxeMichael R Drew
Dec 6, 2005·Life Sciences·Luping Z HuangUrsula H Winzer-Serhan
May 12, 2005·Physiology & Behavior·Kevin M WoolfreyJoshua A Burk
Jun 25, 2005·Alcoholism, Clinical and Experimental Research·Koreen M ClementsPatricia E Wainwright
Apr 18, 2006·Developmental Psychobiology·Anna M LomanowskaPatricia E Wainwright
Mar 8, 2012·Critical Reviews in Toxicology·Louise C Abbott, Ursula H Winzer-Serhan
Apr 25, 2003·Alcoholism, Clinical and Experimental Research·T A GirardP E Wainwright

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