Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination

Neurotoxicology
C KlockeDeborah A Cory-Slechta

Abstract

Accumulating studies indicate that the brain is a direct target of air pollution exposure during the fetal period. We have previously demonstrated that exposure to concentrated ambient particles (CAPs) during gestation produces ventriculomegaly, periventricular hypermyelination, and enlargement of the corpus callosum (CC) during postnatal development in mice. This study aimed to further characterize the cellular basis of the observed hypermyelination and determine if this outcome, among other effects, persisted as the brain matured. Analysis of CC-1+ mature oligodendrocytes in the CC at postnatal days (PNDs) 11-15 suggest a premature maturational shift in number and proportion of total cells in prenatally CAPs-exposed males and females, with no overall change in total CC cellularity. The overall number of Olig2+ lineage cells in the CC was not affected in either sex at the same postnatal timepoint. Assessment of myelin status at early brain maturity (PNDs 57-61) revealed persistent hypermyelination in CAPs-exposed animals of both sexes. In addition, ventriculomegaly was persistent in CAPs-treated females, with possible amelioration of ventriculomegaly in CAPs-exposed males. When oligodendrocyte precursor cell (OPC) pool status ...Continue Reading

Citations

Apr 26, 2020·Environmental Science and Pollution Research International·Arinto Yudi Ponco WardoyoJohan Andoyo Effendi Noor
Dec 24, 2018·Frontiers in Immunology·Chelsea A O'Driscoll, Joshua D Mezrich
Jan 8, 2019·Particle and Fibre Toxicology·Keith Morris-SchafferDeborah A Cory-Slechta
Oct 4, 2020·International Journal of Molecular Sciences·Ryeong-Eun KimKyoung Ja Kwon
Apr 4, 2021·Nanomaterials·Chuanfeng TengShumei Zhai
Nov 22, 2020·Environmental Research·Yong SongGraeme R Zosky

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