Exposure to Helicobacter pylori-positive siblings and persistence of Helicobacter pylori infection in early childhood.

Journal of Pediatric Gastroenterology and Nutrition
Diana T CervantesCheryl S Broussard

Abstract

Cross-sectional studies suggest that Helicobacter pylori may be transmitted between siblings. The present study aimed to estimate the effect of an H pylori-infected sibling on the establishment of a persistent H pylori infection. The authors used data collected from a Texas-Mexico border population from 1998 to 2005 (the "Pasitos Cohort Study"). Starting at age 6 months, H pylori and factors thought to be associated with H pylori were ascertained every 6 months for participants and their younger siblings. Hazard ratios were estimated from proportional hazards regression models with household-dependent modeling. Persistent H pylori infection in older siblings always preceded persistent infection in younger siblings. After controlling for mother's H pylori status, breast-feeding, antibiotic use, and socioeconomic factors, a strong effect was estimated for persistent H pylori infection in an older sibling on persistent infection in a younger sibling (hazard ratio 7.6, 95% confidence interval 1.6-37], especially when the difference in the age of the siblings was less than or equal to 3 years (hazard ratio 16, 95% confidence interval 2.5-112). These results suggest that when siblings are close in age, the older sibling may be an imp...Continue Reading

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Citations

Feb 22, 2012·Current Gastroenterology Reports·Diana A Moya, Karen D Crissinger
Jan 10, 2012·Journal of Pediatric Gastroenterology and Nutrition·Ximena DuquePelayo Correa
Sep 16, 2011·Helicobacter·Josef Sýkora, Marion Rowland
Sep 16, 2011·Helicobacter·Khean-Lee GohYoshio Yamaoka
Apr 4, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Miguel L O'RyanAnne J Lagomarcino
May 27, 2015·PloS One·Nélio VeigaIlídio J Correia
Sep 26, 2016·Archives of Oral Biology·Leonardo Josué Castro-MuñozVirginia Sánchez-Monroy
Dec 12, 2017·BioMed Research International·Alejandra Mendoza-CantúHilda H H Torre-Martínez
May 31, 2018·International Archives of Occupational and Environmental Health·Hassan KheyreBárbara Peleteiro
Dec 6, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yalda LuceroMiguel O'Ryan

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