Exposure to improved nutrition from conception to age 2 years and adult cardiometabolic disease risk: a modelling study

The Lancet Global Health
Nicole D FordAryeh D Stein

Abstract

Low-income and middle-income countries with populations that are chronically undernourished in early life are undergoing a nutrition transition and are experiencing an epidemic of cardiometabolic disease. These dual burdens are thought to be causally related; therefore, the extent to which improvements in early-life nutrition can offset adult-onset disease is important. The aim of this study was to examine whether improvement of protein-energy nutrition from conception to age 2 years can attenuate the risk of cardiometabolic disease. We followed up a cohort of 2392 individuals born between Jan 1, 1962, and Feb 28, 1977, in four villages in Guatemala who had participated in a cluster-randomised protein-energy nutritional supplementation (Atole) trial. Of 1661 participants available for follow-up from Feb 26, 2015, to April 29, 2017, we studied 684 women and 455 men. We assessed cardiometabolic disease risk at ages 37-54 years using anthropometry, fasting and post-challenge glucose, fasting lipid concentrations, and blood pressure. We used generalised linear and logistic regression modelling to estimate the effect of Atole from conception to age 2 years (the first 1000 days) on cardiometabolic disease risk. Exposure to Atole from...Continue Reading

Citations

Jan 5, 2019·Maternal & Child Nutrition·Charlotte E LaneLinda S Adair
Mar 14, 2019·Journal of Diabetes·Anoop MisraKaushik L Ramaiya
Jul 20, 2019·Nutrients·Ilaria CampesiFlavia Franconi
Aug 17, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Chandni Maria JacobMark Hanson
Apr 3, 2020·Food and Nutrition Bulletin·Paúl MelgarMarvin Alvarez
Aug 28, 2019·Diabetologia·Aryeh D SteinChittaranjan S Yajnik
Jul 1, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte E LaneSera L Young
Dec 19, 2019·Maternal & Child Nutrition·Lora L IannottiWilliam F Waters
Nov 28, 2020·The Journal of Nutrition·María J Ramírez-LuzuriagaAryeh D Stein
Mar 19, 2021·KI Reports·Ann C MillerPeter Rohloff
Oct 26, 2021·BMC Nutrition·Christine Chimanuka Murhima'AlikaGhislain Bisimwa Balaluka

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