Exposure to increased levels of estradiol during development can have long-term effects on the response to undernutrition in female rats

Nutritional Neuroscience
B CarrilloH Pinos

Abstract

Undernutrition during development alters the expression of peptides that control energy expenditure and feeding behavior. Estrogens can also modulate these peptides. Here, we analyze whether the early postnatal administration of estradiol modulates the effects of undernutrition on neuroendocrine parameters in adult female Wistar rats. Control rats were fed a control diet. Undernourished pups were submitted to a restricted diet with half of the undernourished rats receiving 0.4 mg/kg s.c. of estradiol benzoate (EB) from postnatal day (P) 6 until P13. Quantitative real-time polymerase chain reaction was performed to determine expression in the hypothalamus of agouti-related peptide (AgRP), proopiomelanocortin (POMC), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript. Plasma estradiol, testosterone, and adiponectin levels were measured by enzyme-linked immunosorbent assay. Total and acylated ghrelin levels were measured in plasma by radioimmunoassay. Insulin and leptin were measured by mulitplex immunoassays. Undernourishment decreased body weight, fat mass, plasma leptin and insulin levels, and hypothalamic POMC mRNA levels. An increase in orexigenic signals AgRP and NPY mRNA levels, and in plasma adiponecti...Continue Reading

References

Jan 1, 1997·Brain Research Bulletin·A Guillamón, S Segovia
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Oct 21, 2000·Progress in Neurobiology·L M Garcia-SeguraL L DonCarlos
Jul 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sheng BiTimothy H Moran
Feb 20, 2004·The Journal of Nutritional Biochemistry·Tatiane da Silva FariaFrancisco J B Sampaio
Jun 9, 2006·Environmental Health Perspectives·Kenneth D R Setchell
Aug 29, 2006·Neuropeptides·Sarika Arora, Anubhuti
Feb 1, 2007·Nutritional Neuroscience·Helena PinosEsther Pérez-Torrero
Apr 24, 2007·Cell·Anthony P CollStephen O'Rahilly
Jul 11, 2007·Journal of Neuroendocrinology·S G Bouret, R B Simerly
Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Qian Gao, Tamas L Horvath
Dec 2, 2008·International Journal of Biological Sciences·María del Carmen Miñana-Solis, Carolina Escobar
Mar 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Rei ShibataToyoaki Murohara
May 13, 2009·Molecular and Cellular Endocrinology·Christopher R Cederroth, Serge Nef
Jun 27, 2009·Physiology & Behavior·Peter C Butera
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Louise E OlofssonAllison W Xu
Jan 29, 2010·The Journal of Nutrition·Mulchand S Patel, Malathi Srinivasan
Mar 30, 2010·Frontiers in Neuroendocrinology·Heather B Patisaul, Wendy Jefferson
Jun 16, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S S Dhillon, D D Belsham
Jun 16, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L E C M SilvaL L K Elias
Oct 12, 2010·Physiology & Behavior·H PinosP Collado
Sep 26, 2012·Nature Neuroscience·Lori M ZeltserMatthias H Tschöp
Aug 2, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lori Asarian, Nori Geary
Aug 31, 2013·Adipocyte·Esther Fuente-MartínJulie A Chowen
Oct 9, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Geetali PradhanYuxiang Sun

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