PMID: 9525262Apr 3, 1998Paper

Exposure to ionizing radiation modifies circulating gastrin levels and gastrointestinal endocrine cell densities in the rat

International Journal of Radiation Biology
T LehyC Linard

Abstract

Gastrointestinal functions, controlled partly by gut peptides, are disturbed by ionizing radiation exposure. The effect of whole-body irradiation on circulating gastrin levels, densities of gastrointestinal endocrine cells and gastric acid secretion was investigated. Rats were exposed to 2 or 6 Gy gamma-radiation. They were killed 3 or 7 days later and compared with shams. Plasma gastrin and basal acid output were measured. Endocrine cells were identified by argyrophilia or immunohistochemistry and their densities estimated. Radiation exposure significantly increased gastrinaemia and gastric acid output at the times studied (p<0.05-p<0.001). Endocrine cells displayed different sensitivities to irradiation. In the gastric mucosa, a 6 Gy dose induced a decrease in fundic argyrophil cell, antral gastrin and somatostatin cell densities, always accentuated 7 days after irradiation, while in the intestinal mucosa it induced an increase, with highest values often at 7 days post-irradiation (p<0.01-p<0.001). This was true for neurotensin cells in the jejunum and ileum, substance P cells in ileum and enteroglucagon cells in the descending colon. Whole-body irradiation in rats significantly alters plasma gastrin levels, and several gut e...Continue Reading

Citations

Oct 20, 2006·International Journal of Radiation Biology·Francesco MarchettiAndrew J Wyrobek
Jul 13, 2011·International Journal of Radiation Biology·Mona A El-GhazalyMohamed T Khayyal
Mar 3, 2015·Journal of Photochemistry and Photobiology. B, Biology·Hanan A Fahmy, Amel F M Ismail

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