Exposure to Lithium and Cesium Through Drinking Water and Thyroid Function During Pregnancy: A Prospective Cohort Study

Thyroid : Official Journal of the American Thyroid Association
Florencia HarariMarie Vahter

Abstract

Impaired thyroid function is a common side effect of lithium medication. Recent data indicate that lithium exposure through drinking water, although providing much lower doses than the medication, may also affect thyroid hormone levels. However, the effects in susceptible groups like pregnant women are not known. In a population-based mother-child cohort in the Argentinean Andes (n = 194), an area with varying concentrations of lithium in the drinking water, we assessed lithium exposure repeatedly during pregnancy by measuring the concentrations in blood using inductively coupled plasma mass spectrometry. The markers of thyroid function included thyrotropin (TSH), free/total thyroxine (fT4/T4), free/total triiodothyronine (fT3/T3), thyroglobulin, and transthyretin in serum, sampled at the same time. Multiple potential confounders, including exposure to arsenic, cesium, and boron (elevated in water) as well as selenium and iodine (essential for thyroid function) were considered. The lithium concentrations in blood [median 25 μg/L (0.0036 mmol/L); range 1.9-145 μg/L (0.000027-0.021 mmol/L)] correlated significantly with those in urine and drinking water (rs = 0.84, p < 0.001, and rs = 0.40, p < 0.001, respectively). Using linear ...Continue Reading

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Citations

Feb 6, 2018·Aging Clinical and Experimental Research·Vladimir Zaichick, Sofia Zaichick
Nov 12, 2017·The Journal of Membrane Biology·Eric JakobssonLaura Pritchet
Sep 6, 2018·Current Medicinal Chemistry·Branislava MedićMilica Prostran
Apr 18, 2019·The Journal of Clinical Endocrinology and Metabolism·Xiaojie SunYuanyuan Li
Sep 2, 2018·Biological Trace Element Research·Hussein Kadhem Al-HakeimKhlowd Mohammed Jasem

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