Exposure to lithium through drinking water and calcium homeostasis during pregnancy: A longitudinal study

Environmental Research
Florencia HarariMarie Vahter

Abstract

There is increasing evidence of adverse health effects due to elevated lithium exposure through drinking water but the impact on calcium homeostasis is unknown. This study aimed at elucidating if lithium exposure through drinking water during pregnancy may impair the maternal calcium homeostasis. In a population-based mother-child cohort in the Argentinean Andes (n=178), with elevated lithium concentrations in the drinking water (5-1660μg/L), blood lithium concentrations (correlating significantly with lithium in water, urine and plasma) were measured repeatedly during pregnancy by inductively coupled plasma mass spectrometry and used as exposure biomarker. Markers of calcium homeostasis included: plasma 25-hydroxyvitamin D3, serum parathyroid hormone (PTH), and calcium, phosphorus and magnesium concentrations in serum and urine. The median maternal blood lithium concentration was 25μg/L (range 1.9-145). In multivariable-adjusted mixed-effects linear regression models, blood lithium was inversely associated with 25-hydroxyvitamin D3 (-6.1nmol/L [95%CI -9.5; -2.6] for a 25μg/L increment in blood lithium). The estimate increased markedly with increasing percentiles of 25-hydroxyvitamin D3. In multivariable-adjusted mixed-effects ...Continue Reading

References

Sep 1, 1992·Biological Trace Element Research·E E Pickett, B L O'Dell
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
May 1, 1981·The Journal of Clinical Endocrinology and Metabolism·E M Brown
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·S T Haden Fuleihan G el-H
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·T W MakS Lee
Feb 13, 2002·Journal of the American College of Nutrition·Gerhard N Schrauzer
Jul 25, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul Lips
Jul 20, 2010·American Journal of Perinatology·Donna D JohnsonBruce W Hollis
Aug 13, 2010·Environmental Science & Technology·Gabriela ConchaMarie Vahter
Jan 22, 2011·Environmental Health Perspectives·Karin BrobergMarie Vahter
Apr 29, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Nestor D KapustaKatharina Leithner-Dziubas
Jul 16, 2011·Annual Review of Nutrition·Patsy M Brannon, Mary Frances Picciano
Aug 13, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ian H de BoerBryan Kestenbaum
Jan 24, 2012·Lancet·Rebecca F McKnightJohn R Geddes
Sep 29, 2012·Reproductive Toxicology·Florencia HarariMarie Vahter
Feb 8, 2013·The British Journal of Nutrition·Petra BrembeckHanna Olausson
Apr 30, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew J DamasiewiczKevan R Polkinghorne
Aug 3, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S N KarrasD G Goulis
Sep 10, 2013·Pflügers Archiv : European journal of physiology·Hajar FakhriFlorian Lang
Nov 22, 2013·The New England Journal of Medicine·Camille E PoweRavi Thadhani
Dec 7, 2013·International Journal of Geriatric Psychiatry·Els Jacoba Maria van MelickToine Cornelis Gerardus Egberts
Mar 14, 2014·The Proceedings of the Nutrition Society·J RedmondI Schoenmakers
Sep 12, 2014·Arquivos brasileiros de endocrinologia e metabologia·Thiago Costa de OliveiraFrancisco de Assis Pereira
Oct 1, 2014·Annals of Human Biology·Cara L EckhardtLisa M Bodnar
Oct 8, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Judith BlaineMoshe Levi
Apr 12, 2015·European Journal of Endocrinology·Rebecca J MoonCyrus Cooper
Sep 4, 2015·Thyroid : Official Journal of the American Thyroid Association·Florencia HarariMarie Vahter

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Citations

Aug 1, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Małgorzata KiełczykowskaJoanna Kocot
Dec 14, 2016·Biological Trace Element Research·Małgorzata KiełczykowskaJoanna Kocot
Jul 18, 2020·The Journal of Nutrition·Marie VahterFlorencia Harari
Dec 5, 2019·Nature Communications·Hye-Bin ChoiNathalie Vigier
Jul 28, 2020·The British Journal of Psychiatry : the Journal of Mental Science·Anjum MemonAllan H Young
Nov 13, 2019·Environmental Science and Pollution Research International·Hafiz Faiq BakhatHafiz Mohkum Hammad
Aug 2, 2018·Biological Trace Element Research·Daria Szklarska, Piotr Rzymski

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