PMID: 3745940Feb 1, 1986Paper

Exposure to low-dose ultraviolet radiation suppresses delayed-type hypersensitivity to herpes simplex virus in mice

The Journal of Investigative Dermatology
S E HowieJ P Maingay

Abstract

Ultraviolet B (UVB) radiation is reported to induce a defect in epidermal antigen presentation which leads to specific suppression of the delayed-type hypersensitivity (DTH) response to trinitrochlorobenzene. We have used a similar system to examine the murine DTH response to herpes simplex virus type 1 (HSV-1). Mice irradiated with 96 mJ/cm2 UVB on shaved dorsal skin 3 days before s.c. injection of live HSV-1 in the flank showed 54-92% suppressed DTH responses to challenge with inactivated virus compared with nonirradiated control animals. If irradiation took place 7 days before inoculation with virus, some suppression of DTH occurred; if 14 days before, no suppression was found. The transient nature of the UVB response is further illustrated by the observation that irradiation with the same dose of UVB 5 h before, or 3 days after, inoculation with virus had no effect on DTH. Once induced, some degree of UVB suppression was found to persist for at least 3 months after irradiation.

Citations

Aug 1, 1989·Photochemistry and Photobiology·M NorvalJ A Ross
Oct 1, 1989·Photochemistry and Photobiology·W L Morison
May 1, 1989·Photochemistry and Photobiology·Y DenkinsM L Kripke
Dec 1, 1988·Photochemistry and Photobiology·J Krutmann, C A Elmets
Jan 1, 1988·Archives of Virology·E Sprecher, Y Becker
Jan 1, 1995·Photochemistry and Photobiology·F P Noonan, F A Lewis
Nov 1, 1995·The Journal of Dermatology·S Kondo, D N Sauder
Dec 7, 2000·Photochemistry and Photobiology·J GarssenH van Loveren
Mar 21, 2002·Immunology and Cell Biology·G J ClydesdaleH K Muller
Jan 1, 1995·Archives of Dermatological Research·G A van Strien, M J Korstanje
Jan 1, 1993·Vox Sanguinis·T KobataS Sekiguchi
May 15, 1998·Photodermatology, Photoimmunology & Photomedicine·A A El-GhorrM Norval
May 1, 1996·Photochemistry and Photobiology·W GoettschH Van Loveren
Jun 1, 1994·The British Journal of Dermatology·M NorvalH Van Loveren
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yumi MatsumuraStephen E Ullrich
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacqueline P McGladePrue H Hart
Feb 1, 1993·Photochemistry and Photobiology·Y M Denkins, M L Kripke
Aug 1, 1996·Photochemistry and Photobiology·M Norval, A A el-Ghorr
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiro KomuraShinichi Sato
Aug 1, 1996·Photochemistry and Photobiology·M L AdamsP D Cruz
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Katie M DixonRebecca S Mason
Mar 1, 1995·Photochemistry and Photobiology·R S ChapmanF Noonan
Mar 1, 1996·Photochemistry and Photobiology·P J Hemelaar, G M Beijersbergen van Henegouwen
Nov 14, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·M Blessmann WeberT Ferreira Cestari
Oct 1, 1990·Photochemistry and Photobiology·F P Noonan, E C De Fabo
Dec 19, 2000·FEMS Immunology and Medical Microbiology·A A El-GhorrM Norval
Jan 23, 1999·Journal of Photochemistry and Photobiology. B, Biology·J LongstrethJ C van der Leun
Jun 25, 2003·Toxicology·M IchihashiT Horikawa
Apr 30, 2021·Italian Journal of Dermatology and Venereology·Matteo MegnaGiuseppe Monfrecola

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