Exposure to Mono-n-Butyl Phthalate in Women with Endometriosis and Its Association with the Biological Effects on Human Granulosa Cells

International Journal of Molecular Sciences
Ya-Ching ChouChii-Ruey Tzeng

Abstract

To study the association between urinary phthalate metabolite levels, endometriosis, and their effects on human granulosa cells, we recruited patients who underwent laparoscopy to confirm endometriosis (n = 123) and control patients (n = 78). Liquid chromatography-tandem mass spectrometry was used to measure the following five urinary phthalate metabolites: mono-n-butyl phthalate (MnBP), mono(2-ethylhexyl) phthalate, monobenzyl phthalate, mono(2-ethyl-5-oxo-hexyl) phthalate, and mono(2-ethyl-5-hydroxyhexyl) phthalate. Urinary MnBP levels were higher in patients with endometriosis than in controls after multivariable logistic regression including the number of deliveries, body mass index, and use of medicine as covariables. MnBP correlates with other phthalate metabolites. Previous studies found that endometriosis was a detrimental condition for granulosa cells. In our study, we observed whether MnBP affected granulosa cells. MnBP treatment altered the gene expression of BIRC5, BUB1B, CDC20, cyclin B1, IL-1β, TNF-α, inhibin-B, StAR, and P450ssc and attenuated the ratio of the mitochondrial membrane potential in human granulosa cells. Moreover, MnBP decreased the expression of the anti-Mullerian hormone. These findings suggest th...Continue Reading

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Citations

Jul 1, 2020·International Journal of Molecular Sciences·Paulina SicińskaBożena Bukowska
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ge LiuHong Wang
Apr 15, 2021·Reproductive Medicine and Biology·Ya-Ching Chou, Chii-Ruey Tzeng
May 10, 2021·The Science of the Total Environment·Wei-Hsiang ChangHsiu-Ling Chen
Jun 6, 2021·The Science of the Total Environment·M Vishnu SreejithUsha K Aravind
Oct 8, 2021·Molecular Reproduction and Development·Inês MesquitaElisa Cairrao

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