Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

Cognitive Neurodynamics
Yingshou XingDezhong Yao

Abstract

Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.

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Citations

Aug 1, 2018·Journal of Neuroscience Research·Xiaofan XiongChen Huang
Mar 30, 2017·Cognitive Neurodynamics·Hui TangJiaquan He
Jan 9, 2019·Frontiers in Behavioral Neuroscience·A Y Rosalie KühlmannJohannes Jeekel
Feb 3, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Klára ŠtillováIvan Rektor

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