Exposure to opioid maintenance treatment reduces long-term mortality

Addiction
Amy E GibsonSusannah O'Brien

Abstract

To (i) examine the predictors of mortality in a randomized study of methadone versus buprenorphine maintenance treatment; (ii) compare the survival experience of the randomized subject groups; and (iii) describe the causes of death. Ten-year longitudinal follow-up of mortality among participants in a randomized trial of methadone versus buprenorphine maintenance treatment. Recruitment through three clinics for a randomized trial of buprenorphine versus methadone maintenance. A total of 405 heroin-dependent (DSM-IV) participants aged 18 years and above who consented to participate in original study. Baseline data from original randomized study; dates and causes of death through data linkage with Births, Deaths and Marriages registries; and longitudinal treatment exposure via State health departments. Predictors of mortality examined through survival analysis. There was an overall mortality rate of 8.84 deaths per 1000 person-years of follow-up and causes of death were comparable with the literature. Increased exposure to episodes of opioid treatment longer than 7 days reduced the risk of mortality; there was no differential mortality among methadone versus buprenorphine participants. More dependent, heavier users of heroin at ba...Continue Reading

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