Abstract
Exposure in swine confinement buildings induces an intense airway inflammation. Twenty-two volunteers, of whom eleven wore a half-mask, were exposed for 3 hr in a swine barn. Blood samples were drawn before and after exposure. The ratio C3b/totalC3 in plasma decreased from 6.8 to 5.0% (p = 0.02) without mask and from 6.6 to 5.9% (p = 0.01) with mask (p = 0.67 between groups). The ratio Bb/totalB decreased from 14.5 to 13.5% (p < 0.01) without and 14.6-13.3% (p = 0.09) with mask (p = 0.25 between groups). Epithelial cells (A549) incubated up to 24 hr with 0.1 mg/mL dust suspensions were analysed for C3, IL-6 and IL-8 secretion. Cumulative C3 synthesis of dust stimulated cell cultures was 43,000 pg/mL compared to 25,000 pg/mL in unstimulated cells. Cumulative dust-induced IL-6 and IL-8 secretion was 200 and 3000 pg/mL, respectively and below detection in unstimulated cells. The activation of complement in vivo and induced C3 synthesis by epithelial cells suggests a role of complement in the airway reaction to organic dust exposure.
References
Mar 1, 1992·Chest·K LarssonL Belin
Jan 1, 1990·American Journal of Industrial Medicine·K J Donham
Mar 1, 1989·Journal of Applied Physiology·O MichelR Sergysels
May 26, 1989·Journal of Chromatography·F Acevedo
Jan 1, 1989·British Journal of Industrial Medicine·K DonhamL Belin
May 1, 1988·The Journal of Clinical Investigation·R C StrunkR J Mason
Jan 1, 1994·Springer Seminars in Immunopathology·K B Reid, M W Turner
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·Z WangK Larsson
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·W ZhipingA Saraf
Feb 1, 1997·The European Respiratory Journal·Z WangL Larsson
Jul 1, 1997·Thorax·B M LarssonK Larsson
Feb 28, 1998·Immunologic Research·A SahuJ D Lambris
Sep 19, 1998·Thorax·L PalmbergK Larsson
Jan 20, 1999·Respiratory Medicine·Z WangK Larsson
Feb 5, 1999·Clinical and Experimental Immunology·Z WangL Palmberg
Apr 9, 1999·Thorax·S O'SullivanL Palmberg
Apr 27, 1999·Electrophoresis·F Acevedo
Aug 12, 1999·Allergy·A EkL Palmberg
Jan 5, 2000·The Journal of Investigative Dermatology·M C PaschS S Asghar
Oct 29, 2000·Journal of Endotoxin Research·W KacaA Weintraub
Feb 24, 2001·Journal of Agricultural Safety and Health·S PedersenM Lyngbye
Feb 24, 2001·Journal of Agricultural Safety and Health·M IversenL Jacobson
Mar 29, 2002·American Journal of Industrial Medicine·Britt-Marie LarssonLena Palmberg
Jul 13, 2002·Chest·Britt-Marie SundbladKjell Larsson
Sep 6, 2002·The European Respiratory Journal·B M SundbladK Larsson
Sep 18, 2004·American Journal of Industrial Medicine·Lena PalmbergKjell Larsson
Citations
Mar 7, 2008·Archives of Toxicology·V LiebersT Brüning
May 23, 2013·Seminars in Immunology·Inken SchmuddeJörg Köhl
Oct 27, 2016·Immunological Reviews·Admar VerschoorJörg Köhl
Sep 4, 2015·Journal of Breath Research·Brian K WalshJohn H Arnold
Oct 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xun ZhangJörg Köhl
Feb 8, 2019·Respiratory Research·Sanjana Mahadev BhatChandrashekhar Charavaryamath