Exposure to Organophosphate esters and metabolic syndrome in adults

Environment International
Kai LuoJun Zhang

Abstract

Organophosphate esters (OPEs) are increasingly used as flame retardants and plasticizers in various products. In vivo and in vitro studies suggest that OPEs can affect metabolic health but the human evidence is lacking. We analyzed data from the U.S. National Health and Nutrition Examination Survey, 2011-2014, to examine the associations between urinary OPE metabolites and metabolic syndrome (MetS) and its components in adults. We included a total of 1157 adults aged ≥20 years who had information on urinary OPE metabolites, components of MetS and essential covariates in the current analyses. MetS was composed of hyperglycemia, hypertension, hypertriglyceridemia, low high-density cholesterol, and central obesity. Binary logistic regression and weighted quantile sum (WQS) regression were used to assess the associations of individual OPE metabolites and OPEs mixture with MetS and its components. All analyses were conducted in men and women separately. Potential effect modification by age, serum total testosterone (TT) level and menopause status were also examined via stratified analyses as well as by testing the significance of the interaction term with exposure. After adjusting for confounders, bis(2-chloroethyl) phosphate (BCEP)...Continue Reading

References

Dec 8, 2004·Environmental Health Perspectives·Jay H LubinPatricia Hartge
Jan 22, 2005·American Heart Journal·Phillippa J MirandaJohn R Guyton
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Feb 10, 2006·International Journal of Andrology·Ted Schettler
Nov 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Annemieke RoosBruce H R Wolffenbuttel
Mar 3, 2010·Environmental Health Perspectives·John D Meeker, Heather M Stapleton
Sep 3, 2010·The Journal of Sexual Medicine·Giovanni CoronaMario Maggi
Dec 10, 2013·Environment International·Kate HoffmanHeather M Stapleton
May 2, 2014·European Thyroid Journal·K Alexander IwenGeorg Brabant
Oct 25, 2014·Environmental Health Perspectives·Kate HoffmanHeather M Stapleton
Jan 31, 2015·The Journal of Clinical Endocrinology and Metabolism·Leen AntonioUNKNOWN EMAS Study Group
May 20, 2015·JAMA : the Journal of the American Medical Association·Maria AguilarRobert J Wong
Mar 2, 2016·Environmental Science & Technology·Liang-Ying LiuAmina Salamova
Oct 18, 2016·Environment International·Kate HoffmanJulie L Daniels
Oct 21, 2016·Reproductive Toxicology·Jerrold J HeindelFrederick Vom Saal
Feb 7, 2017·Environment International·Emma V PrestonThomas F Webster
Feb 7, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·German Cano-SanchoMichele A La Merrill
Mar 21, 2017·Environmental Science & Technology Letters·Kate HoffmanHeather M Stapleton
Apr 13, 2017·Environmental Health : a Global Access Science Source·Megan E RomanoJoseph M Braun
Nov 8, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Elizabeth A KrummTroy A Roepke
Mar 1, 2015·Journal of Agricultural, Biological, and Environmental Statistics·Caroline CarricoPam Factor-Litvak
Mar 19, 2019·Frontiers in Endocrinology·Olga PapalouEvanthia Diamanti-Kandarakis
Mar 28, 2019·Frontiers in Endocrinology·Peter Mancuso, Benjamin Bouchard

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.