Exposure to passive smoking: a test to predict endothelial dysfunction and atherosclerotic lesions

Angiology
Aurelio Leone, A Balbarini

Abstract

Acute exposure to environmental tobacco smoke (ETS) is considered to adversely influence atherogenesis. The aim of this article was to assess whether brachial ultrasonography in subjects with endothelial dysfunction after ETS exposure is associated with atherosclerotic lesions. Never smoker healthy volunteers (n = 18) and subjects with a previous myocardial infarction (MI; n = 10) were studied. Healthy volunteers were 12 men (66%) and 6 women (34%) with a mean age of 34 +/- 9 years. Post-MI subjects were men with a mean age of 53.8 +/- 4.8 years. After assessing endothelial function (by brachial ultrasonography) at rest, study subjects underwent brachial ultrasonography twice: in a smoke-free environment and then in the same environment polluted by cigarette combustion (35 ppm carbon monoxide concentration). Carboxyhemoglobin concentration was measured before and after ETS exposure. Baseline brachial-artery diameter, diameter during reactive hyperemia, and diameter after sublingual nitroglycerin (GTN) administration (endothelium-independent vasodilator) were measured at rest and in both smoke-free and smoking environments. Each study subject acted as their own control. No comparison was made between the two groups. A strong cor...Continue Reading

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Aug 24, 2004·Current Vascular Pharmacology·Aurelio LeoneAlberto Balbarini
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Citations

Feb 22, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·James D SargentReiner Hanewinkel
Jul 12, 2011·Environmental Health Perspectives·Frank PeinemannUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Aug 15, 2013·American Journal of Hypertension·Hideaki KagitaniKazuomi Kario
Feb 1, 2013·Inhalation Toxicology·Andreas D FlourisYiannis Koutedakis
Aug 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Andreas D FlourisYiannis Koutedakis
Apr 3, 2013·International Journal of Environmental Health Research·Petros C DinasAndreas D Flouris
Aug 5, 2010·Angiology·Ibrahim GülNamik Kemal Eryol

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