Exposure to PFDoA causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae

Environmental Pollution
Shengnan ZhangYi Xing

Abstract

Perfluorododecanoic acid (PFDoA), a kind of perfluorinated carboxylic acid (PFCA) with 12 carbon atoms, has an extensive industrial utilization and is widespread in both wildlife and the water environment, and was reported to have the potential to cause a disruption in the thyroid hormone system homeostasis. In this study, zebrafish embryos/larvae were exposed to different concentrations of PFDoA (0, 0.24, 1.2, 6 mg/L) for 96 h post-fertilization (hpf). PFDoA exposure caused obvious growth restriction connected with the reduced thyroid hormones (THs) contents in zebrafish larvae, strengthening the interference effect on the growth of fish larvae. The transcriptional level of genes within the hypothalamic-pituitary-thyroid (HPT) axis was analyzed. The gene expression levels of thyrotropin-releasing hormone (trh) and corticotrophin-releasing hormone (crh) were upregulated upon exposure to 6 mg/L of PFDoA, and iodothyronine deiodinases (dio2) was upregulated in the 1.2 mg/L PFDoA group. The transcription of thyroglobulin (tg) and thyroid receptor (trβ) were significantly downregulated upon exposure to 1.2 mg/L and 6 mg/L of PFDoA. PFDoA could also decrease the levels of sodium/iodide symporter (nis) and transthyretin (ttr) gene ex...Continue Reading

Citations

Jun 27, 2019·Journal of the Royal Society, Interface·Fanwen MengMelvin Khee Shing Leow
Dec 29, 2020·Environmental Toxicology and Chemistry·Amalie Vigdel AskGeir Wing Gabrielsen
Dec 25, 2019·The Science of the Total Environment·Jin Wuk LeePilje Kim
Feb 6, 2021·Frontiers in Endocrinology·Francesca CoperchiniLuca Chiovato

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