Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population

Environment International
Ulla Nordström JoensenHanne Frederiksen

Abstract

Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations. Concentrations of eight simple phenols, six parabens and nine UV filters were analysed in urine from 65 FLG loss-of-function mutation carriers and 130 non-carriers (controls). Regression analyses, controlling for urinary dilution and confounders, were performed to estimate associations between FLG mutation status and chemical concentrations in urine. FLG mutation carriers had 80% (13-180%) higher urinary concentrations of methyl paraben (MeP) and 91% (13-219%) higher concentrations of n-propyl paraben (n-PrP) than controls. For 13 compounds, levels were higher in FLG mutation carriers, although differences were only statistically significant for MeP and n-PrP. Combine...Continue Reading

Citations

Dec 21, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayJames A Yiannias
Jan 17, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayJames A Yiannias
Jan 14, 2021·Environmental Health Perspectives·Emelie Rietz LiljedahlKarin Broberg
Apr 1, 2021·Environmental Health Perspectives·Silke Schmidt
Nov 7, 2018·The Science of the Total Environment·Emelie Rietz LiljedahlKarin Broberg
May 12, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wojciech FrancuzikMargitta Worm
Sep 1, 2017·Environmental Science & Technology·Glenn C MorrisonHanne Frederiksen

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