Abstract
Cardiovascular disease (CVD) results in more than half of the mortality and the majority of morbidity in patients with type 2 diabetes. We aim to evaluate the associations of urinary concentrations of phthalate metabolites with CVD in diabetic patients and explore whether CVD risk factors mediate or interact with these associations. A total of 675 type 2 diabetic participants were enrolled from Shanghai, China, in 2018. CVD was defined as a self-reported diagnosis by a physician including coronary heart disease, myocardial infarction, or stroke; it was further reconfirmed in the records from the registration platform. Ten phthalate metabolites were measured in urine. We found positive associations were found among the level of monoethyl phthalate and monoisobutyl phthalate and CVD (OR 1.138, 95% CI 1.032, 1.254; OR 1.369, 95% CI 1.049, 1.786, respectively). Monoisobutyl phthalate and monobenzyl phthalate were marginally and positively associated with carotid intima-media thickness and common carotid artery diameter, respectively. None of the CVD risk factors, including HOMA-IR, body mass index, lipid profile, or blood pressure, significantly mediated the association between the metabolites and CVD. The conditional indirect effe...Continue Reading
References
May 11, 2002·Environmental Health Perspectives·Jane A HoppinDonna D Baird
Jan 25, 2005·Toxicology·Thomas StrohekerMarie-Christine Chagnon
Feb 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·James H SteinUNKNOWN American Society of Echocardiography Carotid Intima-Media Thickness Task Force
May 7, 2008·Diabetes Care·Caroline S FoxRalph B D'Agostino
May 20, 2008·Atherosclerosis·Maria FranziniAldo Paolicchi
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John D MeekerShanna H Swan
Feb 27, 2010·Environmental Health Perspectives·Jennifer WeuveLauren A Wise
May 31, 2011·Atherosclerosis·P Monica Lind, Lars Lind
Jul 27, 2012·Environmental Health Perspectives·Ulla Nordström JoensenNiels Jørgensen
Sep 3, 2013·European Heart Journal·UNKNOWN Authors/Task Force MembersRobert G Xuereb
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Jan 15, 2014·Critical Reviews in Toxicology·Michael GoodmanDonald R Mattison
Feb 8, 2014·International Journal of Cardiology·Jieli LuGuang Ning
Mar 19, 2014·Environmental Health Perspectives·Qi SunFrank B Hu
Apr 12, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y SongQ Sun
Jul 19, 2014·Environmental Research·Bernice WibergLars Lind
Nov 7, 2015·Endocrine Reviews·A C GoreR T Zoeller
Dec 10, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ningjian WangYingli Lu
Mar 24, 2016·The Journal of Clinical Endocrinology and Metabolism·Ningjian WangYingli Lu
Jun 8, 2017·International Journal of Environmental Research and Public Health·Ruihua DongBo Chen
Aug 27, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Rafael JaimesNikki Gillum Posnack
Nov 28, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gjin NdrepepaAdnan Kastrati
Dec 31, 2017·Regulatory Toxicology and Pharmacology : RTP·Mei Fen ShihJong Yuh Cherng
May 23, 2018·Hypertension·Sanaz SedaghatCoen D A Stehouwer
Aug 19, 2018·Neurotoxicity Research·Anna K WójtowiczKonrad A Szychowski
Sep 23, 2018·Environment International·RuiHua DongBo Chen
Nov 18, 2018·Environmental Research·Katherine W ReevesAntonia M Calafat
Jan 27, 2019·The Science of the Total Environment·Iman Al-SalehSaad Al-Hassan
Feb 13, 2019·Ecotoxicology and Environmental Safety·Ta-Chen SuShu-Li Wang
Jul 14, 2019·Progress in Cardiovascular Diseases·Adam J NelsonNeha J Pagidipati
Aug 2, 2019·Cardiovascular Diabetology·Chiyu WangYingli Lu