Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk

Journal of Endocrinological Investigation
D PaoliL Gandini

Abstract

We carried out a case-control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC). We evaluated 125 TC patients and 103 controls. Seminal fluid examination and organochlorine analysis were performed in all subjects. Cases and controls were also interviewed using a structured questionnaire to collect demographic information, residence, andrological medical history and dietary information. We found that a higher level of reproductive tract birth defects was associated with a higher risk of TC. With regard to diet, cases reported a higher consumption of milk and dairy products than controls. Overall, there was a statistically significant increase in TC risk in cases with detectable values of total polychlorinated organic compounds against controls (14.4 vs. 1.0 %; p < 0.001). TC patients with detectable levels of organochlorines had lower mean semen parameters than those with undetectable levels, although this difference was not statistically significant. The International Agency for Research on Cancer recently included dioxin-like polychlorinated biphenyls (PCBs) in Group 1 of known human carcinogens. Our study confirmed and identified va...Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·H K WeirL Sugar
Jul 25, 2000·Journal of Endocrinological Investigation·L GandiniA Lenzi
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Michael J GarnerUNKNOWN Canadian Cancer Registries Epidemiology Research Group
Sep 24, 2004·International Journal of Andrology·Lennart HardellTorgny Kolmert
Dec 24, 2005·International Journal of Andrology·Lennart HardellMichael Carlberg
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andreas StangKarl-Heinz Jöckel
Mar 8, 2008·International Journal of Cancer. Journal International Du Cancer·Michael B CookKatherine A McGlynn
May 1, 2008·Journal of the National Cancer Institute·Katherine A McGlynnRalph L Erickson
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary L BiggsStephen M Schwartz
Sep 5, 2008·Annual Review of Genomics and Human Genetics·Neil A Youngson, Emma Whitelaw
Feb 19, 2009·Cancer Research·Katherine A McGlynnRalph L Erickson
Mar 24, 2009·Environmental Research·Bridget M MessarosJulia J Wirth
Dec 19, 2009·Environmental Health Perspectives·Mark P PurdueKatherine A McGlynn
Oct 22, 2011·Journal of Andrology·Madhukar Shivajirao Dama, Singh Rajender
Apr 18, 2012·Nature Reviews. Urology·Katherine A McGlynn, Britton Trabert
Apr 24, 2012·Asian Journal of Andrology·Cendrine Geoffroy-SiraudinMarie-Roberte Guichaoua
Mar 19, 2013·The Lancet Oncology·Béatrice Lauby-SecretanUNKNOWN WHO International Agency for Research on Cancer
Jun 21, 2013·The International Journal of Developmental Biology·Jesús Del-MazoMassimo De-Felici
Jun 21, 2013·The International Journal of Developmental Biology·Fabrizio GiannandreaLoredana Gandini
Dec 29, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Charlotte Le CornetFreddie Bray

❮ Previous
Next ❯

Citations

Feb 6, 2016·Reviews in Endocrine & Metabolic Disorders·M F SweeneyC Sonnenschein
Nov 12, 2016·Journal of Endocrinological Investigation·F CoperchiniL Chiovato
Mar 30, 2017·International Journal of Environmental Research and Public Health·Marta BenedettiPietro Comba
May 22, 2018·Nutrition and Cancer·Virginia SignalJason K Gurney
Nov 30, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Dana HashimEmanuela Taioli
Nov 18, 2017·Journal of Endocrinological Investigation·C ForestaA Di Nisio
Oct 3, 2018·Frontiers in Endocrinology·Donatella PaoliFrancesco Lombardo
Jan 7, 2019·Reproductive Biology and Endocrinology : RB&E·Andrea Di Nisio, Carlo Foresta
Feb 28, 2020·Scientific Reports·Muazzama BatoolQamar Saeed
Sep 2, 2020·Environment International·Ramy Abou GhaydaUNKNOWN Russian Children's Study
Mar 5, 2021·Journal of Endocrinological Investigation·F FajaF Lombardo
Mar 7, 2021·International Journal of Environmental Research and Public Health·Mar Requena-MullorRaquel Alarcon-Rodriguez
Jul 17, 2021·The Journal of Clinical Endocrinology and Metabolism·Elvira V BräunerAnders Juul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

The New England Journal of Medicine
D J HunterM S Wolff
Environmental Health Perspectives
Norie SawadaJapan Public Health Center Based Prospective (JPHC) Study Group
Archives of Environmental & Occupational Health
Fiametta NoriIrene Figà-Talamanca
© 2021 Meta ULC. All rights reserved