Exposure to polychlorinated naphthalenes affects GABA-metabolizing enzymes in rat brain

Environmental Toxicology and Pharmacology
Hanna VinitskayaLudmila Zylinska

Abstract

There is substantial evidence that polychlorinated naphthalenes (PCNs) are widespread global environmental pollutants, which accumulate in biota. The aim of our study was to characterize the effect of prolonged PCNs exposure on γ-aminobutyric acid (GABA) metabolism in rat brain regions with a high amount of GABAergic neurons (cerebellum, brain stem and basal ganglia). PCNs mixture was administered intragastrically for 7, 14 and 21 days in a dose 10mg/kg of body weight daily, and next the activity of glutamate decarboxylase (GAD), GABA-aminotransferase (GABA-T), succinic semialdehyde dehydrogenase (SDH) and succinate dehydrogenase (SSA-DH) was assayed. PCNs administration altered all examined activities in the selected brain areas, except GAD in basal ganglia. The results suggest the correlation between PCNs action and disturbance in GABA metabolism in rat brain. Moreover, the chronic PCNs intoxication increased SDH-mediated activation of TCA cycle, and it may be a kind of protective mechanism developed in nervous tissue in response to administration of toxic compounds.

References

Aug 1, 1977·Bulletin of Environmental Contamination and Toxicology·I ChuA Viau
Jan 1, 1988·Bulletin of Environmental Contamination and Toxicology·H J Harmon
Jan 1, 1987·Pharmacology & Therapeutics·M F Sugrue
May 15, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·L T Graham
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·D V Coscina
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·O Hankinson
Dec 15, 1995·Neuroreport·T KainuM Pelto-Huikko
Jan 1, 1996·Free Radical Biology & Medicine·P J VuchetichS J Stohs
Mar 7, 1998·Journal of Toxicology and Environmental Health. Part a·C Weistrand, K Norén
Apr 16, 1998·Archives of Environmental Contamination and Toxicology·A Lundén, K Norén
Feb 15, 2000·Annals of the New York Academy of Sciences·H S WaagepetersenA Schousboe
Mar 25, 2000·Neurochemistry International·H S WaagepetersenA Schousboe
Aug 19, 2000·Archives of Environmental Contamination and Toxicology·D L VilleneuveJ P Giesy
Sep 6, 2002·Chemico-biological Interactions·Timothy P DaltonHoward G Shertzer
Jul 29, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Amy L PraschRichard E Peterson
Dec 12, 2003·Food Additives and Contaminants·J Falandysz
Dec 24, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Amy L PraschWarren Heideman
Apr 20, 2004·Environmental Pollution·J Falandysz
Nov 13, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary A WilliamsonLisa A Opanashuk
Jan 1, 1997·Addiction Biology·N P KanunnikovaS M Zimatkin

Citations

Sep 26, 2015·Reproductive Toxicology·Anna KilanowiczKrystyna Sitarek
Sep 29, 2009·Ecotoxicology and Environmental Safety·Anna Kilanowicz, Malgorzata Skrzypinska-Gawrysiak
Mar 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R G Ahmed
Mar 6, 2012·Neurotoxicology·Anna KilanowiczWieslaw Szymczak
Sep 17, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·J FalandyszMartin Rose
Oct 5, 2006·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·J FalandyszY Noma

Related Concepts

Alcoholic Intoxication, Chronic
4-Aminobutyrate aminotransferase
Basal Ganglia
Brain
Brain Stem
Cerebellum
Gamma-Aminobutyric Acid
Glutamate Decarboxylase
Hematoma, Subdural
Metabolism

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.