Exposure to Polycyclic Aromatic Hydrocarbons Leads to Non-monotonic Modulation of DNA and RNA (hydroxy)methylation in a Rat Model

Scientific Reports
Radu-Corneliu DucaLode Godderis

Abstract

Besides genetic modifications, rapidly growing evidence has linked environmental pollutants with epigenetic variations. To date, only a few studies have been performed on DNA methylation changes of polycyclic aromatic hydrocarbons (PAH), which showed contradictory results. These discrepancies might be partially explained by differences in used agents. Generally in in vitro studies, a single compound is used, while in humans environmental studies, multi-residue exposure is investigated. The present study aimed to study epigenetic alterations induced by multi-residue exposure to PAH. Female Long Evans rats were exposed to a mixture of 16 US-EPA priority PAH, 3 times per week over a 90-day period. The livers were used to assess the (hydroxy)methylation status of genomic DNA/RNA, together with reduced and oxidized forms of glutathione. The results of this study demonstrate that a multi-residue exposure to PAH affects glutathione status, DNA (hydroxy)methylation, and RNA (hydroxy)methylation, together with DNA PAH-adducts formation. In addition, a non-monotonic response relationship was demonstrated between PAH concentration, the levels of glutathione and DNA (hydroxy)methylation levels at environmental relevant doses. This hormetic...Continue Reading

References

Feb 14, 1998·Cancer Letters·K LertratanangkoonM L Thomas
May 1, 1997·Cancer Causes & Control : CCC·P BoffettaP Gustavsson
Jul 23, 1999·Mutation Research·D H Phillips
Apr 20, 2004·Toxicology Letters·Vincent BombailGeorge Orphanides
Oct 7, 2004·Environmental and Molecular Mutagenesis·Lode GodderisDominique Lison
Feb 18, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoung-Ho LeeDaehee Kang
Jun 18, 2010·Journal of Hazardous Materials·Hung-Hsin LiuHsiu-Ling Chen
Jan 19, 2012·International Journal of Epidemiology·Lifang HouAndrea Baccarelli
Jan 19, 2012·Environmental Health Perspectives·Julie B HerbstmanFrederica P Perera
May 2, 2012·Current Genomics·Sunipa MajumdarShahriar Koochekpour
Jan 15, 2013·Briefings in Functional Genomics·Blerta Xhemalce
Jun 8, 2013·Particle and Fibre Toxicology·Bram G JanssenTim S Nawrot
Mar 1, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J CorralesK L Willett
Jul 30, 2014·Journal of the American Chemical Society·Lijuan FuYinsheng Wang
Sep 3, 2014·Genomics·Gabriella Ficz, John G Gribben
Sep 10, 2014·Biochemical and Biophysical Research Communications·Haiyan HuangZhixiong Zhuang
Jun 20, 2015·BioMed Research International·Lode GodderisKirsten Van Landuyt
Sep 22, 2017·Environmental Health Perspectives·Andres CardenasAndrea A Baccarelli

❮ Previous
Next ❯

Citations

Jan 29, 2019·Current Topics in Medicinal Chemistry·Yu BaiGuihua Cui
Nov 30, 2019·International Journal of Environmental Research and Public Health·Carla MartinsPedro M Costa
Jul 7, 2020·Toxicology Mechanisms and Methods·Vesna Smiljevska-RistovskaJasmina Dimitrova-Shumkovska
Mar 22, 2019·Biogerontology·Trim LajqiReinhard Wetzker
Jun 11, 2021·Frontiers in Genetics·Sara B FernandesJonathan D Turner
Aug 15, 2021·Environmental Pollution·Marius Nils MüllerEliete Zanardi-Lamardo

❮ Previous
Next ❯

Software Mentioned

SAS
Graphpad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.