PMID: 9441552Jan 1, 1997Paper

Exposure to radioactive iodine in pregnancy: significance for mother and child

Acta medica Austriaca
E Ogris

Abstract

The embryonal stage in mammalians is characterized by a quick proliferation and differentiation of cells. The special features of this stage of development in all living beings is therefore an increased sensitivity for the exposure with ionizing radiation. Radiation exposure during the prenatal development can therefore lead to various impairments, which can be short-termed or long-termed, showing effects even in the postnatal period. The pattern of radiation induced effects is dependent upon the radiation dose on the one hand and upon the stage of fetal development when radiation exposure occurs on the other hand. Radiation induced effects can be growth retardation, malformations, functional impairments or death as well as increased occurrence of cancer and leukemia during childhood. The main effects of a radiation exposure in the fetal period are: 1) lethal effects for the embryo, 2) malformations and changes in growth or other functional changes, 3) mental retardation, 4) induction of malignomas including leukemia. Lethal effects can be induced experimentally in animals by relatively low radiation doses of 10 cGy, administered before or immediately after the implantation of the embryo. Malformations can be induced if the exp...Continue Reading

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