Exposure to sublethal levels of PCB-126 impacts fuel metabolism and swimming performance in rainbow trout

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Karyne BellehumeurT W Moon

Abstract

Polychlorinated biphenyls (PCBs) are recognized physiological stressors to fish which over time may impair individual performance and perhaps fitness by inducing changes that could have population-level consequences. PCB-126 (3,3',4,4',5-pentachlorobiphenyl) accumulates in lipids and can subsequently be released into the bloodstream during periods of high activity that involve the mobilization of stored fuels to meet with increasing energy demands. The goal of this study was to determine if a sublethal exposure to PCB-126 altered the content of tissue energy supplies (carbohydrates, proteins, amino acids, triglycerides) and impaired swimming performance as well as oxygen consumption in rainbow trout (Oncorhynchus mykiss). Trout were injected intraperitoneally with a single Low (100μgkg(-1)) or High (400μgkg(-1)) dose of PCB-126 then swimming performance and metabolic rates from 1 to 9days post-injection were compared to Control (non-dosed) fish. Liver ethoxyresorufin-O-deethylase (EROD) activity was assessed as an indication of PCB-126 intoxication while plasma and white muscle tissue metabolites were analyzed as an index of physiological disturbance. Swimming performance, assessed using two successive modified critical swimmin...Continue Reading

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Citations

Sep 4, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M M VijayanT P Mommsen
Nov 20, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom
Dec 14, 2017·Environmental Science & Technology·Patrick T GauthierMathilakath M Vijayan

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