Exposure to tetrachloroethylene-contaminated drinking water and time to pregnancy.

Environmental Research
Amelia K WesselinkA Aschengrau

Abstract

The synthetic solvent tetrachloroethylene (PCE), commonly used in dry cleaning operations, is a human neurotoxicant and carcinogen. However, its effect on reproduction is poorly understood, as prior studies have been limited to small occupational cohorts. We examined the association between PCE exposure from contamination of the public drinking water supply and time-to-pregnancy (TTP) in a cohort of mothers from Cape Cod, Massachusetts. The Cape Cod Family Health Study is a retrospective cohort study designed to examine the reproductive and developmental health effects of exposure to PCE-contaminated drinking water. Our analysis included 1565 women who reported 3826 planned pregnancies from 1949 to 1990. Women completed self-administered questionnaires that ascertained TTP for each of her pregnancies, regardless of the outcome, as well as residential history and demographic information. We utilized EPANET water distribution system modeling software and a leaching and transport model to assess PCE exposure for each pregnancy. We used log-binomial regression models to estimate relative risks (RR) and 95% confidence intervals (CI), adjusting for potential confounders. We performed a probabilistic bias analysis to examine the effec...Continue Reading

Citations

Feb 14, 2020·Environmental Science. Processes & Impacts·Ann AschengrauDavid M Ozonoff
Mar 23, 2021·Frontiers in Public Health·Diana M CeballosStephen G Whittaker
Apr 22, 2021·International Journal of Epidemiology·Julie M PetersenMatthew P Fox

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