Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood.

Diabetes
Yanping LiFrank B Hu

Abstract

Early developmental adaptations in response to undernutrition may play an essential role in susceptibility to type 2 diabetes, particularly for those experiencing a "mismatched rich nutritional environment" in later life. We examined the associations of exposure to the Chinese famine (1959-1961) during fetal life and childhood with the risk of hyperglycemia and type 2 diabetes in adulthood. We used the data for 7,874 rural adults born between 1954 and 1964 in selected communities from the cross-sectional 2002 China National Nutrition and Health Survey. Hyperglycemia was defined as fasting plasma glucose ≥6.1 mmol/l and/or 2-h plasma glucose ≥7.8 mmol/l and/or a previous clinical diagnosis of type 2 diabetes. Prevalences of hyperglycemia among adults in nonexposed, fetal exposed, early-childhood, mid-childhood, and late-childhood exposed cohorts were 2.4%, 5.7%, 3.9%, 3.4%, and 5.9%, respectively. In severely affected famine areas, fetal-exposed subjects had an increased risk of hyperglycemia compared with nonexposed subjects (odds ratio = 3.92; 95% CI: 1.64-9.39; P = 0.002); this difference was not observed in less severely affected famine areas (odds ratio = 0.57; 95% CI: 0.25-1.31; P = 0.185). The odds ratios were significant...Continue Reading

References

Feb 5, 1998·Lancet·A C RavelliO P Bleker
Feb 13, 2001·Journal of Neuroendocrinology·L A Welberg, J R Seckl
Jan 26, 2002·British Medical Bulletin·C N Hales, D J Barker
Jan 26, 2002·British Medical Bulletin·A L Fowden, D J Hill
Feb 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C S YajnikS Kellingray
Sep 18, 2004·Science·Peter D Gluckman, Mark A Hanson
Aug 4, 2005·JAMA : the Journal of the American Medical Association·David St ClairLin He
Feb 10, 2007·Journal of Health Economics·Yuyu Chen, Li-An Zhou
Mar 1, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Z YangC Chen
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Dec 26, 2008·JAMA : the Journal of the American Medical Association·Peter H WhincupDonald E Yarbrough
May 12, 2009·Lancet·Peter D GluckmanMary Jane West-Eberhard
Aug 14, 2009·Diabetes Care·Yuna HeXiaoguang Yang
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group

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Citations

Mar 21, 2012·Reviews in Endocrine & Metabolic Disorders·Malgorzata S Martin-Gronert, Susan E Ozanne
Mar 15, 2012·Reviews in Endocrine & Metabolic Disorders·Chittaranjan Sakerlal Yajnik, Urmila Shailesh Deshmukh
Sep 14, 2010·Current Diabetes Reports·Alessandro Doria
Jun 25, 2013·Trends in Endocrinology and Metabolism : TEM·Daniella E Duque-Guimarães, Susan E Ozanne
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·K George M M Alberti, Paul Z Zimmet
Sep 7, 2012·Diabetes, Obesity & Metabolism·M S Martin-Gronert, S E Ozanne
Jul 31, 2012·BMC Cancer·Qing Da LiDa Nan Wang
Oct 2, 2013·BMC Public Health·Zumin ShiAnne W Taylor
Dec 3, 2013·Current Diabetes Reports·Kimberley D Bruce
Apr 9, 2014·BMC Genomics·Yunchao LingJingfa Xiao
Dec 2, 2011·Journal of Nutrition and Metabolism·Delphine Fradin, Pierre Bougnères
Jan 12, 2011·Annual Review of Public Health·L H LumeyEzra Susser
Jan 1, 2013·Current Cardiovascular Risk Reports·Gita Wahi, Sonia S Anand
Nov 8, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yael PasternakMoshe Hod
Apr 11, 2014·Annals of Medicine·Lu Qi
Jul 24, 2015·Journal of Gastroenterology and Hepatology·Jiang-Peng ChenYong-Hong Wang
Feb 26, 2016·Diabetes Care·Arun NandithaPaul Z Zimmet
Jan 30, 2013·Fertility and Sterility·Michal Inbar-FeigenbergRosanna Weksberg
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Nigel J Crowther
Sep 8, 2015·The Lancet. Diabetes & Endocrinology·L H LumeyAlexander M Vaiserman
Dec 20, 2014·Neuroscience and Biobehavioral Reviews·Matthew W HaleLuba Sominsky
Dec 2, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Antony KaspiAssam El-Osta
Jan 17, 2012·Journal of Diabetes·Zachary T Bloomgarden, Guang Ning
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Feb 13, 2013·Clinical Genetics·S T Keating, A El-Osta
Dec 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·S FinerC Yajnik
Sep 3, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Allan VaagLouise G Grunnet
Dec 17, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·S Finer
Aug 5, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Xun TangLarry B Goldstein
Sep 30, 2015·Biopreservation and Biobanking·Oxana P RotarAlexandra O Konradi
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Paul Z ZimmetJonathan E Shaw
Sep 15, 2014·The Lancet. Diabetes & Endocrinology·Ronald Ching Wan MaWeiping Jia
Jun 17, 2015·Diabetologia·Camilla B JensenThorkild I A Sørensen
Jan 27, 2015·Antioxidants & Redox Signaling·Prabhu MathiyalaganAssam El-Osta
Jun 28, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·K W WhitakerT M Reyes
May 23, 2014·Current Opinion in Genetics & Development·Rebecca A Somer, Carl S Thummel
Sep 15, 2014·The Lancet. Diabetes & Endocrinology·Juliana C N ChanGuang Ning
Mar 19, 2014·Diabetes Research and Clinical Practice·Jorge F ElgartJuan J Gagliardino

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BETA
blood draw
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SAS

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