Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Elena H ChartoffWilliam A Carlezon

Abstract

Stress and chronic exposure to drugs of abuse can trigger addictive and depressive disorders. Both stimuli increase activity of dynorphin, a neuropeptide that acts at kappa-opioid receptors (KORs). In humans, KOR agonists cause dysphoria, raising the possibility that dynorphin modulates the depressive-like effects of stress and chronic drug use. We examined if KOR activation alters sensitivity to stimulant drugs by assessing the effects of the selective KOR agonist, salvinorin A (SalvA), on cocaine-induced locomotor activity and c-Fos expression. Acute administration of SalvA blocked the locomotor-stimulant effects of cocaine, whereas repeated SalvA together with concomitant exposure to activity testing chambers potentiated the locomotor response to a cocaine challenge. In contrast, repeated SalvA administered in home cages rather than the activity chambers failed to potentiate the locomotor response to a cocaine challenge. One potential explanation for these findings is that activation of KORs disrupts context conditioning: acute locomotor responses to SalvA alone did not fully habituate with repeated testing in the activity chambers. The effects of SalvA on locomotor activity paralleled its effects on cocaine-induced c-Fos ex...Continue Reading

References

Nov 1, 1992·The International Journal of Neuroscience·E A Kiyatkin
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R SpanagelT S Shippenberg
Mar 1, 1992·Brain Research. Molecular Brain Research·Y L HurdC R Gerfen
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·K L McDanielH A Tilson
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·G F KoobF E Bloom
Jul 7, 1988·European Journal of Pharmacology·T S Shippenberg, A Herz
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Aug 15, 1986·Science·A PfeifferH M Emrich
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1984·Psychopharmacology·J P HermanM Le Moal
Jun 1, 1994·Journal of Ethnopharmacology·D J Siebert
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·U ArvidssonM W Wessendorf
Sep 1, 1993·Brain Research. Molecular Brain Research·R SpanglerM J Kreek
Dec 15, 1994·The Journal of Comparative Neurology·A MansourS J Watson
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jan 1, 1997·Annual Review of Psychology·R C Kessler
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·T S Shippenberg, W Rea
Oct 6, 1997·Science·G F Koob, M Le Moal
Feb 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A MarkouG F Koob
Jun 17, 1998·Molecular Neurobiology·R E Harlan, M M Garcia
May 6, 1999·Psychopharmacology·R SinhaS O'Malley
Jul 27, 2000·Annals of the New York Academy of Sciences·N K Mello, S S Negus
Aug 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bryan L RothRichard B Rothman
Oct 29, 2002·Psychopharmacology·Yavin ShahamJane Stewart
Jan 17, 2004·Psychopharmacology·Mark S TodtenkopfWilliam A Carlezon
Sep 3, 2004·Behavioural Pharmacology·A Badiani, T E Robinson
Sep 17, 2004·Life Sciences·Feng Yan, Bryan L Roth
Jan 22, 2005·Journal of Medicinal Chemistry·Thomas A MunroFeng Yan
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vladimir I CheferToni S Shippenberg

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Citations

Nov 12, 2013·Neuroscience and Biobehavioral Reviews·Agnes J JasinskaYavor Yalachkov
Apr 19, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabriella AvielloRaffaele Capasso
Feb 23, 2011·Journal of Natural Products·Anthony LozamaThomas E Prisinzano
Aug 31, 2013·Journal of Natural Products·Madan Kumar PaudelSatoshi Morimoto
Aug 24, 2010·Acta Pharmacologica Sinica·Yu-hua WangJing-gen Liu
Aug 27, 2009·Organic & Biomolecular Chemistry·Denise S SimpsonThomas E Prisinzano
Dec 1, 2011·The Journal of Pharmacology and Experimental Therapeutics·S Stevens NegusKenner C Rice
Dec 10, 2013·Hormones and Behavior·Jamshid FarajiGerlinde A S Metz
Jan 22, 2014·Behavioural Brain Research·Cindee F RoblesBrian C Trainor
Oct 18, 2011·Cellular and Molecular Life Sciences : CMLS·H A TejedaR Henriksson
Dec 1, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Rathi MahendranMunidasa Winslow
Aug 5, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena H ChartoffMitchell F Roitman
Jan 7, 2016·Frontiers in Neuroscience·Elena H Chartoff, Maria Mavrikaki
Oct 2, 2009·Peptides·Richard J Bodnar
Jun 6, 2009·Pharmacology & Therapeutics·William A CarlezonBruce M Cohen
Oct 1, 2008·Neuroscience Letters·Pieter BeerepootHenry Szechtman
Jun 25, 2013·Human Psychopharmacology·Jolanta B Zawilska, Jakub Wojcieszak
Dec 22, 2009·Natural Product Reports·Katherine M Prevatt-Smith, Thomas E Prisinzano
May 15, 2008·Chemical Reviews·Thomas E Prisinzano, Richard B Rothman
Jul 20, 2016·Natural Product Reports·Rongtao LiKuo-Hsiung Lee
Nov 5, 2016·Neuropharmacology·Santhanalakshmi SundaramurthySammanda Ramamoorthy
Oct 1, 2011·International Journal of Toxicology·Daniela BraidaMariaelvina Sala
Mar 30, 2018·The American Journal on Addictions·Joseph El-Khoury, Evelyne Baroud
Jul 28, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samantha M FortinMitchell F Roitman
Aug 2, 2014·Behavioural Pharmacology·Elena H Chartoff, William A Carlezon
Dec 11, 2019·Neuroscience and Biobehavioral Reviews·Corey B PuryearConnie Sanchez
Feb 7, 2021·Pharmaceuticals·Andreia Machado Brito-da-CostaÁurea Madureira-Carvalho

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