A positive association between latitude and prostate cancer mortality has been interpreted to indicate that ultraviolet radiation (UVR) protects against development of this cancer. We aimed to examine this hypothesis. We compared exposure between 210 cases and 155 controls. Childhood sunburn (odds ratio 0.18, 95% CI 0.08-0.38), regular foreign holidays(0.41, 0.25-0.68), sunbathing score (0.83, 0.76-0.89), and low exposure to UVR (3.03, 1.59-5.78) were associated with development of prostate cancer. Furthermore, cases with low UVR exposure developed cancer at a younger median age (67.7 years, IQR 61.5-74.6) than cases with higher exposure (72.1 years, 67.5-76.4); p=0.006. These findings are compatible with UVR having a protective role against prostate cancer.
Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation
New perspectives on vitamin D sources in Germany based on a novel mathematical bottom-up model of 25(OH)D serum concentrations
Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors
Prostate cancer risk and exposure to ultraviolet radiation: further support for the protective effect of sunlight
Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation
A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light - a further advantage of vegan diets
Susceptibility and modifier genes in cutaneous basal cell carcinomas and their associations with clinical phenotype
Assessment of lifetime cumulative sun exposure using a self-administered questionnaire: reliability of two approaches
Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk
The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude
Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
Baseline serum 25-hydroxyvitamin d levels in men undergoing radical prostatectomy: is there an association with adverse pathologic features?
Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases
The angular distributions of ultraviolet spectral irradiance at different solar elevation angles under clear sky conditions
Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer
Polymorphism in the nuclear excision repair gene ERCC2/XPD: association between an exon 6-exon 10 haplotype and susceptibility to cutaneous basal cell carcinoma
Sun exposure may increase risk of prostate cancer in the high UV environment of New South Wales, Australia: a case-control study
Phase 2 trial of weekly intravenous 1,25 dihydroxy cholecalciferol (calcitriol) in combination with dexamethasone for castration-resistant prostate cancer
International comparisons of prostate cancer mortality rates with dietary practices and sunlight levels
Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries
PTCH polymorphism is associated with the rate of increase in basal cell carcinoma numbers during follow-up: preliminary data on the influence of an exon 12-exon 23 haplotype
Associations between G/A1229, A/G3944, T/C30875, C/T48200 and C/T65013 genotypes and haplotypes in the vitamin D receptor gene, ultraviolet radiation and susceptibility to prostate cancer
Life course sun exposure and risk of prostate cancer: population-based nested case-control study and meta-analysis
Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation
Vitamin D Status, Latitude and their Associations with Some Health Parameters in Children: National Food and Nutrition Surveillance
Vitamin D status and cardiometabolic risk factors across latitudinal gradient in Iranian adults: National food and nutrition surveillance
Targeting multiple signaling pathways as a strategy for managing prostate cancer: multifocal signal modulation therapy
Studies of associations between disability in multiple sclerosis, skin type, gender and ultraviolet radiation
Polymorphisms in the vitamin D receptor gene, ultraviolet radiation, and susceptibility to prostate cancer
Re: A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk. S. I. Berndt, J. L. Dodson, W. Y. Huang and K. K. Nicodemus, J Urol 2006; 175: 1613-1623
1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2), potentiate the effects of ionising radiation on human prostate cancer cells
Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health
Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort
Strengths and limitations of current epidemiologic studies: vitamin D as a modifier of colon and prostate cancer risk
Does testosterone mediate the relationship between vitamin D and prostate cancer? A systematic review and meta-analysis protocol
What are the frequency, distribution, and functional effects of vitamin D receptor polymorphisms as related to cancer risk?
An initial melanoma diagnosis may increase the subsequent risk of prostate cancer: Results from the New South Wales Cancer Registry
Association of serum 25-hydroxyvitamin D concentration with anthropometric measures in children and adolescents: the CASPIAN-V study
Serum 25-hydroxyvitamin D concentrations and risk of prostate cancer: results from the Prostate Cancer Prevention Trial
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
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