Exposure to work-related levels of swine dust up-regulates CD106 on human alveolar macrophages

American Journal of Industrial Medicine
Hans Jürgen HoffmannRonald Dahl

Abstract

Exposure to dust from swine confinement buildings, causes an inflammatory response. Monocyte recruitment to the murine lung after instillation of lipopolysaccharide (LPS) has been shown to partially depend on CD106/VCAM1. We wanted to determine whether this can be confirmed in man. Non-naïve persons bearing personal air samples were exposed for 3 hr in a swine confinement building, and were bronchoscopied before and after exposure. Blood samples were taken at the time of bronchoscopy. Expression of adhesion molecules on leukocytes was investigated by flow cytometry in bronchoaveloar lavage (BAL) and blood. Expression of CD106 on alveolar macrophages, but not on neutrophils or T cells in BAL or blood, was up-regulated in proportion to the amount of LPS that individuals were exposed. This argues for requirement of CD106 during inflammatory recruitment of monocytes to the human lung.

References

Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·K A PachecoL J Rosenwasser
Apr 12, 2000·The European Respiratory Journal·Y CormierC Duchaine
May 15, 2001·Occupational and Environmental Medicine·K RadonD Nowak
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Ulrich MausJügen Lohmeyer
May 2, 2003·Journal of Immunological Methods·Heddy ZolaUNKNOWN IUIS/WHO Subcommittee

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Citations

Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·Dick Heederik, Torben Sigsgaard
Jun 20, 2017·American Journal of Respiratory and Critical Care Medicine·Torben Sigsgaard, John Balmes

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