Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate

Nature Neuroscience
Aziz MoqrichA Patapoutian

Abstract

Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons: TrkA is expressed in neurons that sense temperature and noxious stimuli, and TrkC is expressed in proprioceptive neurons that sense body position. Neurotrophin signaling through these receptors is required for cell survival. To test whether neurotrophins have an instructive role in sensory specification, we expressed rat TrkC from the TrkA (also known as Ntrk1) locus in mice. The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes.

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Citations

Nov 6, 2010·Archives of Pharmacal Research·Eduardo Gascon, Aziz Moqrich
Jul 5, 2005·Nature Reviews. Neuroscience·Maria Fitzgerald
Aug 30, 2008·Neural Development·Ken-ichi InoueYoshiaki Ito
Dec 9, 2014·Frontiers in Biology·Li-Ya Qiao
Apr 16, 2014·The Journal of Experimental Medicine·Kevin J O'DonovanJian Zhong
Jul 30, 2014·Cellular and Molecular Life Sciences : CMLS·Jesse V Veenvliet, Marten P Smidt
Aug 26, 2010·Gene Expression Patterns : GEP·Wassim LeghaAziz Moqrich
Feb 21, 2007·Differentiation; Research in Biological Diversity·Andreas MonteliusPatrik Ernfors
Feb 17, 2015·Cell Reports·Ana ReyndersAziz Moqrich
Oct 3, 2006·Developmental Biology·Lei LeiLuis F Parada
Apr 3, 2012·Developmental Biology·William J Pavan, David W Raible
Nov 25, 2014·Nature Neuroscience·Joel W BlanchardKristin K Baldwin
Mar 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·James N SleighGiampietro Schiavo
Jan 24, 2007·Nature Reviews. Neuroscience·Frédéric Marmigère, Patrik Ernfors
Sep 3, 2010·Nature·Vassiliki NikoletopoulouYves-Alain Barde
Apr 14, 2005·Journal of Neurobiology·Bariş GençReha S Erzurumlu
Mar 1, 2019·Scientific Reports·Miriam CandelasPierre-François Méry
May 12, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Amrita PathakBruce D Carter
Oct 23, 2019·The Journal of Clinical Investigation·Zhu LiAaron W James
Apr 4, 2008·Development·Souichiro NakamuraTakashi Shiga

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