Expression Analysis of Long Non-Coding RNAs Related With FOXM1, GATA3, FOXA1 and ESR1 in Breast Tissues.

Frontiers in Oncology
Bita HassaniFarkhondeh Pouresmaeili

Abstract

Breast cancer is the most common neoplasm among females. Estrogen receptor (ESR) signaling has a prominent impact in the pathogenesis of breast cancer. Among the transcription factors associated with ESR signaling, FOXM1, GATA3, FOXA1 and ESR1 have been suggested as a candidate in the pathogenesis of this neoplasm. In the current project, we have designed an in silico approach to find long non-coding RNAs (lncRNAs) that regulate these transcription factors. Then, we used clinical samples to carry out validation of our in silico findings. Our systems biology method led to the identification of APTR, AC144450.1, linc00663, ZNF337.AS1, and RAMP2.AS1 lncRNAs. Subsequently, we assessed the expression of these genes in breast cancer tissues compared with the adjacent non-cancerous tissues (ANCTs). Expression of GATA3 was significantly higher in breast cancer tissues compared with ANCTs (Ratio of mean expressions (RME) = 4.99, P value = 3.12E-04). Moreover, expression levels of APTR, AC144450.1, and ZNF337.AS1 were elevated in breast cancer tissues compared with control tissues (RME = 2.27, P value = 5.40E-03; Ratio of mean expressions = 615.95, P value = 7.39E-19 and RME = 1.78, P value = 3.40E-02, respectively). On the other hand, t...Continue Reading

References

Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·R V HochR J Weigel
Aug 30, 2000·Nature·C M PerouD Botstein
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Jan 15, 2003·BMC Bioinformatics·Gary D Bader, Christopher W V Hogue
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Aug 7, 2004·Bioinformatics·James M Wettenhall, Gordon K Smyth
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Josée LaganièreVincent Giguère
Jan 3, 2013·Current Medicinal Chemistry·F LumachiS M M Basso
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Maricruz Anaya-RuizJose Luis Martin Perez-Santos
Oct 30, 2014·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Bramanandam ManavathiVijay Narasimha Reddy Gajulapalli
Oct 22, 2015·American Journal of Clinical Pathology·Brandi C McCleskeyShi Wei
Dec 8, 2015·Gene Expression·Motoki TakakuPaul A Wade
Feb 18, 2016·European Journal of Endocrinology·J S Carroll
Oct 28, 2016·Molecular Cancer Therapeutics·Shuang LiuZhongming Zhao
Mar 31, 2017·Breast Cancer Research : BCR·Miriam Ragle AureUNKNOWN OSBREAC
May 4, 2017·Oncotarget·Sen ZhaoRolf I Skotheim
Jun 2, 2017·Experimental and Therapeutic Medicine·Huang ZhangXusheng Fan
Jun 13, 2017·Oncogene·W-X PengY-Y Mo
Sep 6, 2018·Breast Cancer Research : BCR·Alexey A LeontovichAntonino B D'Assoro
Apr 9, 2019·Molecular Oncology·Arunagiri Kuha Deva Magendhra RaoSamson Mani
Apr 14, 2020·Experimental and Molecular Pathology·Mehdi MohebiMohammad Taheri
Nov 24, 2020·Journal of Translational Medicine·Wei MaFeng Jin
Dec 24, 2020·Nature Reviews. Molecular Cell Biology·Luisa StatelloMaite Huarte

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Software Mentioned

Bioconductor
R package “ limma
R
MCODE
BayesGLM
Affy package
Cytoscape
TFcheckpoint
Molecular Complex Detection ( MCODE ) Plugin
cluster Profiler

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