Expression analysis of novel striatal-enriched genes in Huntington disease.

Human Molecular Genetics
Gelareh MazareiB R Leavitt

Abstract

Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown. Expression studies of diseased human post-mortem brain, as well as different mouse models exhibiting striatal degeneration, have demonstrated changes in the expression of many important genes with a large proportion of changes being observed in the striatal-enriched genes. These investigations have raised questions about how enrichment of particular transcripts in the striatum can lead to its selective vulnerability to neurodegeneration. Monitoring the expression changes of striatal-enriched genes during the course of the disease may be informative about their potential involvement in selective degeneration. In this study, we analyzed a Serial Analysis of Gene Expression (SAGE) database (www.mouseatlas.org) and compared the mouse striatum to 18 other brain regions to generate a novel list of striatal-enriched transcripts. These novel striatal-enriched transcripts were subsequently evaluated for expression changes in the YAC128 mouse model of HD, and differentially expressed transcripts were further examined in human post-mortem caudate samples. We identif...Continue Reading

References

May 1, 1993·Molecular and Cellular Biology·F P GillespieS C Wadsworth
May 18, 2000·Human Molecular Genetics·R Luthi-CarterJ M Olson
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·J A BibbP Greengard
Aug 6, 2002·Journal of Neuroimmunology·Kenichi SakuraiGene M Shearer
Sep 25, 2002·Neurobiology of Disease·Virginia Macdonald, Glenda Halliday
Jun 19, 2003·Human Molecular Genetics·Elizabeth J SlowMichael R Hayden
Jul 4, 2003·Genome Research·Michel de ChaldéeJean-Marc Elalouf
Oct 2, 2003·Annals of Neurology·Adam RosenblattChristopher A Ross
Apr 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Patrick B AllenPaul Greengard
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Christophe CorvolDenis Hervé
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy M Van RaamsdonkMichael R Hayden
Jun 9, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erik KwidzinskiIngo Bechmann
Sep 27, 2005·Journal of Neurochemistry·Jeremy M Van RaamsdonkBlair R Leavitt
Nov 8, 2005·Science·Michael PlattenLawrence Steinman
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Asim S SiddiquiMarco A Marra
Jan 13, 2006·Journal of Neurochemistry·Paula A DesplatsElizabeth A Thomas
Feb 10, 2006·Human Molecular Genetics·Angela HodgesRuth Luthi-Carter
May 16, 2006·Neurobiology of Disease·Paolo GuidettiRobert Schwarcz
Aug 24, 2006·Genome Biology·Danielle Thierry-Mieg, Jean Thierry-Mieg
Sep 20, 2006·Journal of Neuroscience Research·Elizabeth A Thomas
Jun 28, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Erik Kwidzinski, Ingo Bechmann
Nov 6, 2007·Developmental Cell·Sara J S SimonsonShigeki Miyamoto
Jun 25, 2008·Molecular and Cellular Biology·Jieya ShaoMarc I Diamond
Jul 1, 2008·The European Journal of Neuroscience·Joana M Gil, Ana Cristina Rego
Jul 16, 2008·The Journal of Experimental Medicine·Maria BjörkqvistSarah J Tabrizi

❮ Previous
Next ❯

Citations

May 15, 2013·Human Molecular Genetics·Fengli WangTie-Shan Tang
May 14, 2014·Progress in Neurobiology·Jean-François SchmouthGuy A Rouleau
May 3, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marta AmaralFlaviano Giorgini
Apr 5, 2011·Seminars in Cell & Developmental Biology·Katie J Wolfe, Douglas M Cyr
Jun 22, 2013·Journal of Neurochemistry·Gelareh MazareiBlair R Leavitt
Nov 22, 2015·Drug Discovery Today·Jason R SmithGilles J Guillemin
Sep 24, 2015·Journal of Huntington's Disease·Gelareh Mazarei, Blair R Leavitt
Mar 17, 2015·Seminars in Cell & Developmental Biology·Daniel C Maddison, Flaviano Giorgini
Oct 14, 2014·Frontiers in Cellular Neuroscience·Laetitia FrancelleEmmanuel Brouillet
Apr 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Carlo BredaFlaviano Giorgini
Sep 19, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi Creus-Muncunill, Michelle E Ehrlich
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dániel SandiLászló Vécsei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.