Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues

Cell and Tissue Research
Xiao-Lan HuLibo Yao

Abstract

N-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression pattern of Ndrg2 protein in mouse embryos at various gestational ages and in a variety of adult mouse tissues. Ndrg2 immunoreactivity was generally localized to the cytoplasm. During mouse development, Ndrg2 expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was developmentally dynamic, being generally lower in the early stages of development and markedly increasing during later stages. Ndrg2 expression was also observed in a variety of adult mouse tissues, particularly in the heart and brain. This is the first demonstration of Ndrg2 protein expression in both embryonic and adult mouse tissues. Our results suggest that NDRG2 plays important roles in histogenesis and organogenesis.

References

Jun 22, 2000·Biochemical and Biophysical Research Communications·K L AgarwalaT Miyata
Sep 28, 2000·Biochemical and Biophysical Research Communications·H ParkC H Graham
Jun 19, 2001·Biochimica Et Biophysica Acta·W ZhaoY Mao
Dec 18, 2001·Molecular Carcinogenesis·E Gómez-CaseroJ L Jorcano
Apr 30, 2002·Brain Research. Developmental Brain Research·Takeshi OhkiMinoru Takeda
Jun 20, 2002·The Journal of Biological Chemistry·Sheerazed BoulkrounNathalie Courtois-Coutry
Nov 15, 2002·Histochemistry and Cell Biology·Pascale LachatFred T Bosman
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Yanchun DengMarie Chia-mi Lin
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshinobu WakisakaToru Iwaki
Feb 27, 2004·The Journal of Biological Chemistry·James G BurchfieldCarsten Schmitz-Peiffer
Mar 3, 2004·Annals of the New York Academy of Sciences·Nancy R Nichols
May 11, 2004·Biological & Pharmaceutical Bulletin·Toshihiko SugikiIchiro Kudo
Jun 4, 2004·Advances in Experimental Medicine and Biology·Ivan DingBruce Fenton
Jun 23, 2004·Neurobiology of Disease·Cathy MitchelmoreNiels A Jensen
Jul 13, 2004·The Journal of Biological Chemistry·Kyung-Tae KimSam W Lee
Sep 21, 2004·The Journal of Biological Chemistry·Susanne SteinPeng Liang

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Citations

Jan 5, 2011·Histochemistry and Cell Biology·Zhongchan SunHaichang Wang
Mar 1, 2012·Histochemistry and Cell Biology·Stefan Hübner, Athina Efthymiadis
Dec 7, 2011·Journal of Molecular Histology·Lijuan LiuYanchun Deng
Sep 2, 2008·Applied Biochemistry and Biotechnology·Xinping LiuLibo Yao
Feb 27, 2014·Nature Communications·Shingo NakahataKazuhiro Morishita
Aug 11, 2007·DNA and Cell Biology·Emelie SvenssonUrban Gullberg
Jan 26, 2013·DNA and Cell Biology·Shiying ShaoXuefeng Yu
Aug 3, 2010·Journal of Experimental & Clinical Cancer Research : CR·Jian-Jun MaTing-Yi Bao
Jun 21, 2013·The Journal of Endocrinology·Milan ObradovicEsma R Isenovic
May 13, 2014·Cell and Tissue Research·Gabriele FlüggeEberhard Fuchs
Feb 4, 2010·Cellular and Molecular Life Sciences : CMLS·Lan ShenLibo Yao
Sep 27, 2012·Digestive Diseases and Sciences·Xiaojing ChangDongqiu Dai
Sep 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jiandong YangKefeng Dou
Nov 18, 2006·Biochemical and Biophysical Research Communications·Jing ZhangLibo Yao
Sep 6, 2015·Acta Biochimica Et Biophysica Sinica·Kaifeng LinYan Li
Jul 24, 2012·Developmental Biology·Huang ZhuXizhi Guo
Dec 3, 2014·Asian Pacific Journal of Tropical Medicine·Sheng QiangMin Huang
Dec 18, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yan LiLibo Yao
Jul 27, 2007·The Journal of Biological Chemistry·Mark O WielpützRobert Rauh
Feb 6, 2018·Advanced Pharmaceutical Bulletin·Ali GolestanZahra Mojtahedi
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Veerle MelotteManon van Engeland
Mar 23, 2017·Future Oncology·Mehrdad Asghari EstiarKeivan Majidzadeh-A
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Libo YaoXuewu Liu
May 30, 2019·BMC Molecular and Cell Biology·Bilal A MirVictoria C Foletta

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