Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear

Molecular and Cellular Neurosciences
Negusse HabtemichaelWolf J Mann

Abstract

Hearing impairment is a worldwide health problem. Employing semi-quantitative immunological detection methods, we found that the apoptosis inhibitor protein Birc5 is expressed in cell types critical for hearing perception. In the guinea pig model, moderate noise exposure causing only a temporary mean hearing impairment of 33dB significantly enhanced Birc5 expression in the spiral ligament, nerve fibers and the organ of Corti. In contrast, intratympanic gentamicin injection inducing permanent cell damage and mean hearing loss of 24dB correlated with a significant Birc5 downregulation in the ligament, nerve fibers and the organ of Corti. The cytoprotective activity of the guinea pig and human Birc5 protein was confirmed by cloning of the gene and by subsequent ectopic expression and challenging studies against the ototoxin gentamicin in epithelial and auditory cell models. As the mammalian cochlea is unable to regenerate upon damage, these data suggest that modulation of Birc5 expression may represent a novel physiological mechanism to protect the inner ear against stress-induced cell damage. Hence, the targeted modulation of Birc5 levels may lead to novel otoprotective therapeutic strategies.

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Citations

Mar 23, 2011·Traffic·Carolin BierRoland H Stauber
Oct 11, 2017·Journal of Molecular Cell Biology·Christian SchrenkShirley K Knauer
Jan 31, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Désirée WünschRoland H Stauber
Feb 27, 2015·Biological Chemistry·Désirée WünschShirley K Knauer
Jun 16, 2017·BMC Gastroenterology·Alexandra ScheerRabea Verhaegh
Dec 4, 2019·Stem Cell Research & Therapy·Cheng ChengRenjie Chai
Sep 13, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ulf R HeinrichSebastian Strieth
Apr 26, 2019·Journal of Cellular Physiology·Yasamin PahlavanAlireza Khabbazi
Aug 28, 2021·Biological Chemistry·Désirée GülRoland H Stauber

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