Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs

Experimental Lung Research
Chandrashekhar CharavaryamathBaljit Singh

Abstract

The role of N-myristoyltransferase and calcineurin is well established in signaling pathways. However, there are no data on their expression and activities in normal and inflamed lungs. The mechanisms of lung inflammation induced following administration of lipopolysaccharides (LPS) or exposure to swine barn air remain unclear. Therefore, we examined expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs of rats. Histopathology showed acute inflammation in the lungs of rats exposed to barn air or LPS but not of control rats. There was no difference in the activities of N-myristoyltransferase and calcineurin among the control, barn-exposed, and LPS-treated rat lungs. Although N-myristoyltransferase and calcineurin were localized in airway epithelium, blood vessel walls, alveolar macrophages, and septa in the lungs of rats from all the groups, the staining intensity was increased in the lungs from rats exposed to intravenous LPS or barn air. Densitometric analyses of Western blots of 55- and 60-kDa polypeptide bands corresponding to N-myristoyltransferase and calcineurin, respectively, in the lung homogenates revealed no differences among the groups. These results show that expression of ...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1991·Analytical Biochemistry·M J King, R K Sharma
Mar 1, 1990·The American Review of Respiratory Disease·R A PauwelsM E Van Der Straeten
Nov 1, 1995·Journal of the National Cancer Institute·B A MagnusonR K Sharma
Jan 1, 1994·Annual Review of Biochemistry·D R JohnsonJ I Gordon
Aug 1, 1995·Molecular and Cellular Biochemistry·R V RajuR K Sharma
Jun 1, 1997·Chest·A SenthilselvanT S Hurst
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·P F VogelzangC P van Schayck
Mar 16, 2000·Molecular and Cellular Biochemistry·R V RajalaR K Sharma
Mar 17, 2000·Immunological Reviews·P ZhangS Nelson
Jul 13, 2000·Biochemical and Biophysical Research Communications·R V RajalaR K Sharma
Oct 4, 2000·Physiological Reviews·F Rusnak, P Mertz
Jun 13, 2001·Oncogene·F MaciánA Rao
Jun 21, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Thorn
Jul 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Orlando F BuenoJeffery D Molkentin
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Apr 3, 2003·The Journal of Clinical Investigation·Graciela AndoneguiPaul Kubes
Mar 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hirohito MitsuyamaHisao Seo
Apr 14, 2004·Current Medicinal Chemistry·Sara Martínez-Martínez, Juan Miguel Redondo
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ponniah SelvakumarRajendra K Sharma
May 25, 2004·Journal of Cellular Biochemistry·Ponniah SelvakumarRajendra K Sharma
Dec 2, 2004·Canadian Journal of Physiology and Pharmacology·Rajendra K Sharma
Dec 9, 2004·International Immunology·Kiyoshi Takeda, Shizuo Akira
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Jaspal Singh, David A Schwartz
Jun 4, 2005·Respiratory Research·Chandrashekhar CharavaryamathBaljit Singh
Sep 1, 2005·Biochemical and Biophysical Research Communications·Ponniah SelvakumarRajendra K Sharma
Dec 13, 2005·Journal of Neurochemistry·Ashakumary LakshmikuttyammaRajendra K Sharma
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Kyathanahalli S JanardhanBaljit Singh
Apr 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel C RoweDouglas T Golenbock
Jul 19, 2006·Progress in Lipid Research·Ponniah SelvakumarRajendra K Sharma
Nov 1, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Chandrashekhar CharavaryamathBaljit Singh
Jan 25, 2007·Neurosurgery Clinics of North America·H Michael Keyoung, Steven A Goldman
Mar 3, 2007·Annual Review of Biochemistry·Myeong Sup Lee, Young-Joon Kim
Aug 19, 2007·European Journal of Immunology·Matthias SieberRia Baumgrass
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana M FernandezIgnacio Torres-Aleman
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young Jun KangPatricia P Jones
Nov 13, 2007·Progress in Neurobiology·Ashakumary LakshmikuttyammaRajendra K Sharma
Jan 22, 2008·Experimental Lung Research·Chandrashekhar CharavaryamathBaljit Singh
Mar 7, 2008·Archives of Toxicology·V LiebersT Brüning

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Occupational Medicine and Toxicology
Chandrashekhar CharavaryamathBaljit Singh
Journal of Occupational Medicine and Toxicology
Lakshman Nihal Angunna GamageBaljit Singh
© 2022 Meta ULC. All rights reserved