Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Maria Carolina FlorianHartmut Geiger

Abstract

The small RhoGTPase Cdc42 is mechanistically linked to aging of multiple tissues and to rejuvenation of hematopoietic stem cells in mice. However, data validating Cdc42 activity and expression as biomarker for aging in humans are still missing. Here, we hypothesized that Cdc42 might serve as a novel biomarker of aging in older adults and therefore we determined Cdc42 activity and expression levels in peripheral blood cells from a cohort of 196 donors. We investigated the association of these parameters with both chronological and biological aging. We also tested in this cohort of older adults a recently published algorithm determining chronological age based on DNA methylation profiles. A positive correlation with chronological age was found for both the level of Cdc42 mRNA and the level of active Cdc42 protein (the GTP bound form). Notably, the level of Cdc42 mRNA as well as total protein showed a specific strong association to cardiovascular disease and Cdc42 mRNA levels also to a history of myocardial infarction. In summary, these data validate Cdc42 as a blood biomarker of both chronological aging as well as aging-associated diseases like cardiovascular disease and myocardial infarction.

References

Sep 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedG S Rubin
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Dec 14, 2002·Trends in Cell Biology·Sun Young Moon, Yi Zheng
Mar 17, 2004·Journal of Cell Science·Sandrine Etienne-Manneville
Jun 3, 2006·Blood·Zhenlan XingHartmut Geiger
Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lei WangYi Zheng
Feb 26, 2008·Cell·Derrick J RossiIrving L Weissman
May 16, 2008·Mechanisms of Ageing and Development·Luigi A Warren, Derrick J Rossi
Feb 28, 2009·Aging Cell·Richard A KerberRichard M Cawthon
May 28, 2010·Disease Models & Mechanisms·David Piccin, Cindi M Morshead
May 9, 2012·Cell Stem Cell·Maria Carolina FlorianHartmut Geiger
Apr 16, 2013·Nature Reviews. Immunology·Hartmut GeigerM Carolina Florian
Oct 22, 2013·Nature·Maria Carolina FlorianHartmut Geiger
Feb 5, 2014·Genome Biology·Carola Ingrid WeidnerWolfgang Wagner
Jul 25, 2014·Nature·Luigi FontanaSimon Melov
Nov 27, 2014·The New England Journal of Medicine·Siddhartha JaiswalBenjamin L Ebert
Apr 24, 2015·Aging Cell·Valter D LongoLuigi Fontana
Nov 28, 2015·Trends in Immunology·Michael D DenkingerHartmut Geiger

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Citations

Jun 29, 2017·American Journal of Respiratory and Critical Care Medicine·Elizabeth SapeyDavid R Thickett
Aug 11, 2018·Blood·Graham P Pawelec
Mar 29, 2019·Cardiovascular Research·Aldo BonaventuraLuca Liberale
Jan 8, 2020·Cancers·Polina Zjablovskaja, Maria Carolina Florian
Jul 15, 2018·Seminars in Immunopathology·Graham Pawelec
Jun 24, 2020·Drug Discovery Today·Christos ErmogenousJanet M Lord

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