Expression and alternative splicing of the cyclin-dependent kinase inhibitor-3 gene in human cancer

The International Journal of Biochemistry & Cell Biology
W Douglas CressJie Wu

Abstract

The cyclin-dependent kinase inhibitor-3 (CDKN3) gene encodes a dual-specificity protein tyrosine phosphatase that dephosphorylates CDK1/CDK2 and other proteins. CDKN3 is often overexpressed in human cancer, and this overexpression correlates with reduced survival in several types of cancer. CDKN3 transcript variants and mutations have also been reported. The mechanism of CDKN3 overexpression and the role of CDKN3 transcript variants in human cancer are not entirely clear. Here, we review the literature and provide additional data to assess the correlation of CDKN3 expression with patient survival. Besides the full-length CDKN3 encoding transcript and a major transcript that skips exon 2 express in normal and cancer cells, minor aberrant transcript variants have been reported. Aberrant CDKN3 transcripts were postulated to encode dominant-negative inhibitors of CDKN3 as an explanation for overexpression of the perceived tumor suppressor gene in human cancer. However, while CDKN3 is often overexpressed in human cancer, aberrant CDKN3 transcripts occur infrequently and at lower levels. CDKN3 mutations and copy number alternation are rare in human cancer, implying that neither loss of CDKN3 activity nor constitutive gain of CDKN3 ex...Continue Reading

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Citations

Aug 23, 2018·PLoS Genetics·Ignacio Monedero CobetaJonathan Benito-Sipos
Mar 14, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Zide ChenHongyan Liu
Jan 11, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Li-Ming GaoShu-Feng Xu
Jun 23, 2018·Database : the Journal of Biological Databases and Curation·Jin LiPeng Yu
Jun 18, 2021·World Journal of Gastroenterology : WJG·Zai-Sheng YeLu-Chuan Chen

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