Expression and cellular localization of the transcription factor NeuroD1 in the developing and adult rat pineal gland

Journal of Pineal Research
Analía E CastroEstela Muñoz

Abstract

Circadian rhythms govern many aspects of mammalian physiology. The daily pattern of melatonin synthesis and secretion is one of the classic examples of circadian oscillations. It is mediated by a class of neuroendocrine cells known as pinealocytes which are not yet fully defined. An established method to evaluate functional and cytological characters is through the expression of lineage-specific transcriptional regulators. NeuroD1 is a basic helix-loop-helix transcription factor involved in the specification and maintenance of both endocrine and neuronal phenotypes. We have previously described developmental and adult regulation of NeuroD1 mRNA in the rodent pineal gland. However, the transcript levels were not influenced by the elimination of sympathetic input, suggesting that any rhythmicity of NeuroD1 might be found downstream of transcription. Here, we describe NeuroD1 protein expression and cellular localization in the rat pineal gland during development and the daily cycle. In embryonic and perinatal stages, protein expression follows the mRNA pattern and is predominantly nuclear. Thereafter, NeuroD1 is mostly found in pinealocyte nuclei in the early part of the night and in cytoplasm during the day, a rhythm maintained i...Continue Reading

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Citations

Mar 29, 2016·Journal of Pineal Research·Haijie YuBertil Hille
Sep 25, 2018·The Journal of Comparative Neurology·María P Ibañez RodriguezEstela M Muñoz
Nov 20, 2016·PloS One·María P Ibañez RodriguezEstela M Muñoz
Mar 12, 2020·International Journal of Molecular Sciences·Natalia Jorgelina PradoEmiliano Raúl Diez

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