PMID: 9441740Jan 27, 1998Paper

Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway

Genomics
M OndaNobuo Sakaguchi

Abstract

To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction pathway. The human alpha 4 has sequence identities with murine alpha 4 of 83.4% nucleotide and 82.9% amino acid sequence, and a stretch of consensus motifs in the carboxyl terminal is conserved among the related genes of human, mouse, yeast, and rice. The gene is expressed as a 1.4-kb mRNA in the spleen, lymph node, thymus, appendix, peripheral blood leukocytes, bone marrow, fetal liver, heart, brain, placenta, skeletal muscle, kidney, and pancreas. The anti-human alpha 4 antibody detected a 45-kDa protein in human lymphoid cell lines. Moreover, human alpha 4 (IGBP1) gene is located at q13.1-q13.3 on chromosome X.

References

Sep 14, 1990·Journal of Immunological Methods·J P Siegel, H S Mostowski
Apr 1, 1991·Molecular and Cellular Biology·A SuttonK T Arndt
Mar 21, 1986·Journal of Theoretical Biology·W R Taylor

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Citations

Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·B RaughtN Sonenberg
Jan 7, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jianye LiuDan Xie
May 14, 2016·Biochemical and Biophysical Research Communications·Michele L LeNoue-NewtonBenjamin W Spiller
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Allen D Everett, David L Brautigan
Aug 19, 2007·The Journal of Biological Chemistry·Mei KongCraig B Thompson
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·O J ShahL S Jefferson
Jul 18, 2000·American Journal of Physiology. Cell Physiology·G YueD C Eaton

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