PMID: 16536995Mar 16, 2006Paper

Expression and clinical significance of apoptosis-related oncogenes in stage I-II non-small cell lung cancer

Ai zheng = Aizheng = Chinese journal of cancer
Dao-Feng WangZhi-Hua Zhu

Abstract

The prognosis of stage I-II non-small cell lung cancer (NSCLC) after operation is related to many factors. Apoptosis-related oncogenes play an important role in occurrence and development of tumors. This study was to investigate the expression and prognostic significance of representative apoptosis-related oncogenes (Survivin, Bcl-2, Bax, and Fas) in stage I-II NSCLC. The expression of Survivin, Bcl-2, Bax, and Fas in 115 specimens of stage I-II NSCLC and 20 specimens of non-tumor lung tissue were detected by SP immunohistochemistry. The positive rates of Survivin and Bcl-2 were significantly higher in NSCLC than in non-tumor lung tissues (62.61% vs. 10.00%, P<0.001; 49.57% vs. 15.00%, P<0.05); the positive rates of Bax and Fas were significantly lower in NSCLC than in non-tumor lung tissues (31.30% vs. 65.00%, P<0.05; 46.96% vs. 80.00%, P<0.05). TNM stage and positive expression of Survivin were independent prognostic factors of stage I-II NSCLC (P<0.01). The survival time of patients was significantly shorter in Survivin-positive group than in Survivin-negative group [(33+/-7) months vs. (52+/-9) months, P<0.05]. Apoptosis-related oncogenes may have some impacts on the occurrence and development of stage I-II NSCLC. TNM stage...Continue Reading

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