Expression and Clinical Significance of Elafin in Inflammatory Bowel Disease

Inflammatory Bowel Diseases
Wei ZhangHuaHong Wang

Abstract

The expression of elafin in inflammatory bowel disease (IBD) is controversial. Here, we detected the expression of elafin in the peripheral blood and colonic mucosa of patient with IBD and then explored its role and value in assessing the activity and severity of IBD. Sixty-eight patients with IBD were selected as an experimental group. The control group included 38 healthy individuals. The expression of elafin mRNA in peripheral blood leukocytes and in serum was detected by qRT-PCR and enzyme-linked immunosorbent assay, respectively. The inflamed and noninflamed tissues were collected by colonoscopy. The expression of elafin in the intestinal mucosa was determined by immunohistochemistry staining and qRT-PCR. The expression of elafin between groups and among each stage of IBD was compared. The correlations of elafin expression with erythrocyte sedimentation rate and C-reactive protein were determined by Spearman's correlation analysis and with clinical disease activity indices (Best Crohn's Disease Activity Index and modified Mayo scores) by Pearson's correlation analysis. Elafin mRNA levels decreased significantly in active ulcerative colitis (UC) but increased in remission UC. However, in Crohn's disease (CD), we did not det...Continue Reading

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Citations

Jul 2, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Toshiko TanakaLuigi Ferrucci
Oct 21, 2018·Pediatric Research·Emanuela FerrettiJean-François Beaulieu
Jul 10, 2019·Gastroenterology Research and Practice·Yun LiuGuigen Teng
Oct 22, 2020·Scientific Reports·Prachi KothiyalSuchitra K Hourigan

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