Expression and clinical significance of GRIM-19 in lung cancer.

Medical Oncology
Xiao-Yun FanRong-Yu Liu

Abstract

We investigated the expression of gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) in lung cancer, a recently discovered cell death regulatory gene. Over-expression of GRIM-19 potentially suppresses proliferation and promotes tumor cell apoptosis. However, the expression of GRIM-19 in human lung cancer has not yet been thoroughly investigated. All of the specimens were obtained using CT-guided lung puncture or bronchial biopsy. The expression of GRIM-19 was investigated using immunohistochemistry. The expression level of GRIM-19 was significantly different between lung cancer and lung inflammation. A relatively lower GRIM-19 expression level was also found in small cell lung carcinomas compared to squamous cell carcinoma and adenocarcinoma. No significant difference between GRIM-19 expression in squamous cell carcinoma and adenocarcinoma was determined. Downregulation of GRIM-19 was found in non-small cell lung carcinomas stages III-IV compared to stages I-II, indicating a negative correlation between the expression level of GRIM-19 and the stage of the primary lesion (T). Furthermore, we found GRIM-19 to be primarily located in the cytoplasm in lung inflammation tissues, but located in the nucleus in lun...Continue Reading

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Citations

Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sudhakar KalakondaDhananjaya V Kalvakolanu
May 9, 2015·Molecular Medicine Reports·Wei ZhangDuo Zhang
Dec 26, 2015·Fish & Shellfish Immunology·Ting PengYuan Liu
Sep 14, 2015·Human Pathology·Miao HaoXianling Cong
May 5, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ying ZhouWeihua Xiao
Sep 24, 2016·Cytokine & Growth Factor Reviews·Shreeram C Nallar, Dhan V Kalvakolanu
Sep 19, 2019·Clinical and Experimental Pharmacology & Physiology·Haili LinHong Chen
Aug 10, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Xin WangYi Huang

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