Expression and clinical significance of microRNA-1246 in human oral squamous cell carcinoma

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Lan LiaoMeng Zhang

Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that may function as oncogenes or tumor suppressors. Previous studies have shown that the expression level of miR-1246 was enhanced in multiple types of cancers. However, the expression of miR-1246 in human oral squamous cell carcinoma (OSCC) and its prognostic values remain unclear. Quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to analyze the expression of miR-1246 in 106 pairs of matched normal and tumor tissue samples. The chi-square test was used to examine the associations between miR-1246 expression and the clinicopathological characters. The survival curves were constructed by the Kaplan-Meier method. The influence of each clinical variable on survival was examined by the Cox multivariate regression analysis. The expression level of miR-1246 was significantly higher in tumor tissues and oral cancer cell lines than in normal controls (p<0.01). High expression of miR-1246 was found to significantly correlate with nodal status (p=0.015), TNM stage (p=0.005), and tumor grade (p=0.002). Enhanced miR-1246 correlated significantly with patient survival (p<0.01). In multivariate analysis, we found that miR-1246 expression was an independent prognosti...Continue Reading

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Citations

Oct 9, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Qijun ZhangXiaopo Lin
Oct 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stella ChaiStephanie Ma
Mar 29, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Makoto ChumaNaoya Sakamoto
Apr 30, 2016·International Journal of Molecular Sciences·Erika LarreaCharles H Lawrie
Jun 18, 2020·Frontiers in Oncology·Ruma Dey GhoshSusanta Roychoudhury
Feb 8, 2020·Cancers·Pei-Ling HsiehCheng-Chia Yu
Sep 16, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·T YuY Wu
Apr 4, 2021·International Journal of Molecular Sciences·Kumar RishabhAjaikumar B Kunnumakkara

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
Sigmaplot12

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