Expression and clinical significance of S100 family genes in patients with melanoma

Melanoma Research
Ting-Feng XiongDong Li

Abstract

Genes in the S100 family are abnormally expressed in a variety of tumor cells and are associated with clinical pathology, but their prognostic value in melanoma patients has not yet been fully elucidated. In this study, we extracted and profiled S100 family mRNA expression data and corresponding clinical data from the Gene Expression Omnibus database to analyze how expression of these genes correlates with clinical pathology. Compared with normal skin, S100A1, S100A13, and S100B were expressed at significantly higher levels in melanoma samples. S100A2, S100A7, S100A8, S100A9, S100A10, S100A11, and S100P were all highly expressed in primary melanoma samples but were expressed at low levels in metastatic melanoma, and all of these genes were strongly correlated with each other (P<0.001). We found the expression of these S100 family genes to be significantly correlated with both lymphatic and distant melanoma metastasis, as well as with American Joint Committee on Cancer grade but not with Clark's grade, age, or sex. This suggests that expression of these genes may be related to the degree of tumor invasion. Although further validation through basic and clinical trials is needed, our results suggest that the S100 family genes have...Continue Reading

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Jul 30, 2020·Cancers·Chantal AllgöwerJohannes Lemke
Dec 24, 2018·International Journal of Molecular Sciences·Tannith M NoyeCarmela Ricciardelli
Oct 25, 2020·Proteomics. Clinical Applications·Ai-Jun GuoA-Man Xu
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Oct 5, 2021·The Journal of International Medical Research·Yu-Lei HouHui Chen

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